Effect of yohimbine on nerve growth factor mRNA and protein levels in rat hippocampus

E. A. Stone, J. S. Manavalan, D. A. Basham, G. Bing

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Activation of noradrenergic receptors has been shown to increase expression of nerve growth factor (NGF) gene in brain cells in vitro. The present studies were undertaken to determine if this stimulation was effective in vivo as well. Rats were administered the norepinephrine-releasing drug. yohimbine (YOH), and had their hippocampi assayed for NGF mRNA and protein at various times after the injection. It was found that yohimbine caused a 3-fold increase of NGF mRNA levels at 24 h. Protein levels, however, were unaltered at this time. Thus norepinephrine release in vivo appears to be sufficient for increasing mRNA level but not for translation to protein.

Original languageEnglish
Pages (from-to)11-13
Number of pages3
JournalNeuroscience Letters
Volume167
Issue number1-2
DOIs
StatePublished - Feb 14 1994

Keywords

  • Nerve growth factor mRNA
  • Nerve growth factor protein
  • Noradrenergic stimulation
  • Yohimbine

ASJC Scopus subject areas

  • Neuroscience (all)

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