Effects of β-(N-Methylamino)-L-alanine on Cytoskeletal Proteins of Erythrocyte Membranes

D. Allan Butterfield, Nathan C. Hall, Scott J. Cross

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The interaction of the amino acid β-(N-methylamino)-L-alanine, a neurotoxin found in the seed of the false sago palm, with erythrocyte membranes has been monitored by electron paramagnetic resonance techniques of spin labeling. This neurotoxin did not alter the motion or order of bilayer lipids, but a highly-significant and dose-dependent alteration in the physical state of cytoskeletal proteins was observed. These results are discussed in reference to potential mechanisms involved in the neurotoxicity produced by β-(N-methylamino)-L-alanine and in reference to the unusual neurological disorders among the Chamorro population of Guam and other Marianas Islands.

Original languageEnglish
Pages (from-to)417-420
Number of pages4
JournalChemical Research in Toxicology
Issue number4
StatePublished - 1993

ASJC Scopus subject areas

  • Toxicology


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