Effects of Δ9-tetrahydrocannabinol and social context on marijuana self-administration by humans

Thomas H. Kelly, Richard W. Foltin, Matthew T. Mayr, Marian W. Fischman

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The effects of time of day and social context on daily patterns of marijuana self-administration were examined in two groups of three adult male marijuana smokers during a 12-day residential study. Days were divided into 6.5-h work and social-access periods. Order of occurrence (i.e., work before social access or social access before work) was counterbalanced between groups and reversed for both groups on day 8. Up to eight marijuana cigarettes (0.0% or 2.3% Δ9-THC) could be smoked each day. Stable patterns of marijuana smoking were observed across days for each subject. Three subjects smoked more marijuana during the social-access period, regardless of when it occurred. The other smoked more marijuana during the first period, regardless of whether it was a work or social-access period. The number of marijuana cigarettes smoked was unrelated to THC content. In contrast, subjective reports of "High," "Liking," "Potency" and "Drug" on visual-analog scales were increased on active marijuana days. Subjective reports of drug effects were not predictive of drug self-administration.

Original languageEnglish
Pages (from-to)763-768
Number of pages6
JournalPharmacology Biochemistry and Behavior
Issue number3
StatePublished - Nov 1994

Bibliographical note

Funding Information:
ACKNOWLEDGEMENTS This research was supported by Grant DA-03476 from the National Institute on Drug Abuse. The assistance of Cleeve Emurian, Jerry Locklee, Lisa King, and Michelle Woodland are gratefully acknowledged. A preliminary report of these results was presented at the 1991 meeting of the International Study Group Investigating Drugs as Reinforcers, and a portion of these data were published in a festschrift in honor of Joseph V. Brady (9).


  • Marijuana, Self-administration, Δ-Tetrahydrocannabinol, Context, Reinforcement
  • Subjective effects, Human

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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