Effects of a Single Intravenous Glucocorticoid Dose on Biogenic Amine Levels in Cat Lumbar Spinal Cord

Edward D. Hall, Patricia A. McGinley

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Abstract: The effects of a single large intravenous dose of methylprednisolone on the steady state levels of dopamine, norepinephrine, and 5‐hydroxytryptamine in cat lumbar spinal cord, as a function of dose (15, 30, or 90 mg/kg) and time (1 or 24 h) after administration, were examined by high performance liquid chromatography with electrochemical detection. Methylprednisolone produced a dose‐related increase in the levels of dopamine and 5‐hydroxytryptamine, but not norepinephrine, measured at 1 h. The effect of the single glucocorticoid dose was biphasic, however, as measurement of the three amines at 24 h showed each to be depressed below the levels found in untreated animals. The possible mechanistic basis and the significance of these glucocorticoid effects are discussed.

Original languageEnglish
Pages (from-to)1787-1790
Number of pages4
JournalJournal of Neurochemistry
Volume38
Issue number6
DOIs
StatePublished - Jun 1982

Keywords

  • Biogenic amines
  • Methylprednisolone
  • Spinal cord

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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