Abstract
Abstract: The effects of a single large intravenous dose of methylprednisolone on the steady state levels of dopamine, norepinephrine, and 5‐hydroxytryptamine in cat lumbar spinal cord, as a function of dose (15, 30, or 90 mg/kg) and time (1 or 24 h) after administration, were examined by high performance liquid chromatography with electrochemical detection. Methylprednisolone produced a dose‐related increase in the levels of dopamine and 5‐hydroxytryptamine, but not norepinephrine, measured at 1 h. The effect of the single glucocorticoid dose was biphasic, however, as measurement of the three amines at 24 h showed each to be depressed below the levels found in untreated animals. The possible mechanistic basis and the significance of these glucocorticoid effects are discussed.
Original language | English |
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Pages (from-to) | 1787-1790 |
Number of pages | 4 |
Journal | Journal of Neurochemistry |
Volume | 38 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1982 |
Keywords
- Biogenic amines
- Methylprednisolone
- Spinal cord
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience