Effects of amphetamines and small related molecules on recovery after stroke in animals and man

Larry B. Goldstein

doi:10.1016/S0028-3908(99)00249-X

Effects of amphetamines and small related molecules on recovery after stroke in animals and man

Larry B. Goldstein

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Drugs modulating the levels of specific central neurotransmitters may influence both the rate and amount of functional recovery after focal brain injuries such as stroke. Because such drugs may be effective long after brain injury, the 'therapeutic window' may be widened beyond the first few hour after stroke and an entirely new avenue for pharmacological intervention may be possible. The impact of drugs affecting norepinephrine and γ-aminobutyric acid have been among the most extensively studied in the laboratory, and preliminary clinical data suggest similar effects in humans. Copyright (C) 1999.

Original language	English
Pages (from-to)	852-859
Number of pages	8
Journal	Neuropharmacology
Volume	39
Issue number	5
DOIs	https://doi.org/10.1016/S0028-3908(99)00249-X
State	Published - Apr 2000

Keywords

Amphetamine
GABA
Norepinephrine
Recovery
Stroke

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/S0028-3908(99)00249-X

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abstract = "Drugs modulating the levels of specific central neurotransmitters may influence both the rate and amount of functional recovery after focal brain injuries such as stroke. Because such drugs may be effective long after brain injury, the 'therapeutic window' may be widened beyond the first few hour after stroke and an entirely new avenue for pharmacological intervention may be possible. The impact of drugs affecting norepinephrine and γ-aminobutyric acid have been among the most extensively studied in the laboratory, and preliminary clinical data suggest similar effects in humans. Copyright (C) 1999.",

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AB - Drugs modulating the levels of specific central neurotransmitters may influence both the rate and amount of functional recovery after focal brain injuries such as stroke. Because such drugs may be effective long after brain injury, the 'therapeutic window' may be widened beyond the first few hour after stroke and an entirely new avenue for pharmacological intervention may be possible. The impact of drugs affecting norepinephrine and γ-aminobutyric acid have been among the most extensively studied in the laboratory, and preliminary clinical data suggest similar effects in humans. Copyright (C) 1999.

KW - Amphetamine

KW - GABA

KW - Norepinephrine

KW - Recovery

KW - Stroke

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Effects of amphetamines and small related molecules on recovery after stroke in animals and man

Abstract

Keywords

ASJC Scopus subject areas

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