Purpose of reviewVarious groups have explored the effect of apolipoprotein E (APOE) on neurodegeneration through nutritional and metabolic alterations. In this review, we hope to summarize recent findings in humans as well as preclinical APOE models.Recent findingsMetabolic pathways including lipid metabolism appear to play a large role in the pathophysiology of Alzheimer's disease. Carrier status of the E4 variant of the APOE gene is the strongest genetic risk factor for Alzheimer's disease, and increasing evidence suggests that E4 carriers may respond differently to a host of dietary and metabolic-related treatments. A new appreciation is forming for the role of APOE in cerebral metabolism, and how nutritional factors may impact this role.SummaryConsidering the role dietary factors play in APOE-associated cognitive decline will help us to understand how nutritional interventions may facilitate or mitigate disease progression.
|Number of pages
|Current Opinion in Lipidology
|Published - Feb 1 2019
Bibliographical noteFunding Information:
L.A.J. was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P30 GM127211, and grant R01 AG060056 from the National Institute of Aging.
© 2019 Lippincott Williams and Wilkins. All rights reserved.
- Alzheimer's disease
- apolipoprotein E
- dietary interventions
- high-fat diet
- insulin resistance
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Nutrition and Dietetics
- Cardiology and Cardiovascular Medicine
- Cell Biology