Effects of apomorphine on novelty-induced place preference behavior in rats

M. T. Bardo, M. Lacy, B. A. Mattingly

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Adult male rats were exposed to one of two different stimulus compartments by being placed into the compartment for 30 min on each of eight consecutive days. Following this exposure, each rat was administered 0, 0.05, 0.1, 0.5 or 5.0 mg/kg apomorphine. Thirty min after injection, each animal was given free-choice access to the familiar (exposed) compartment and to the novel (nonexposed) compartment. As expected, saline-injected control animals displayed a preference for the novel compartment. This novelty preference was disrupted in animals given either 0.05 or 0.1 mg/kg apomorphine, but not in animals given either 0.5 or 5.0 mg/kg apomorphine. The disruption in novelty preference by the low doses of apomorphine did not reflect a disruption of locomotor activity, as there was no direct relationship between the preference for novelty and the rate of horizontal or vertical activity among the different treatment groups. Instead, the low doses of apomorphine may have inhibited dopamine function by blocking presynaptic autoreceptors selectively, and thus the reinforcing effect of the novel stimulation may have been attenuated.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalPharmacology Biochemistry and Behavior
Issue number1
StatePublished - Sep 1990

Bibliographical note

Funding Information:
We appreciate the assistance of S. Bowling, C. Crawford and J. Rowlett in observing some of the video tapes of animals' behavior. This research was supported by United States Public Health Service grant DA05312.


  • Apomorphine
  • Dopamine
  • Locomotor activity
  • Novelty
  • Place preference

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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