Effects of calcium channel activators on the response of rabbit aortic rings to alpha1-receptor agonists: Evidence for two modes of action

Michael Babich, Brent T. Butler, Michael T. Piascik

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The interaction between activators of the calcium channel and the αi-radreno-ceptor has been studied in isolated rabbit aortic rings. The data obtained in these investigations are not consistent with the idea of a homogenous population of αi-receptors which trigger contraction via a single pathway. Our results suggest that calcium channel activators reveal two modes of spasmogenic action for αi-adrenoceptor agonists. Furthermore, we have shown that there may be multiple drug recognition sites on the αi-receptor.

Original languageEnglish
Pages (from-to)176-184
Number of pages9
JournalPharmacology
Volume39
Issue number3
DOIs
StatePublished - 1989

Keywords

  • Alpha receptor
  • BAY K 8644
  • Calcium channel activators

ASJC Scopus subject areas

  • Pharmacology

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