Abstract
The interaction between activators of the calcium channel and the αi-radreno-ceptor has been studied in isolated rabbit aortic rings. The data obtained in these investigations are not consistent with the idea of a homogenous population of αi-receptors which trigger contraction via a single pathway. Our results suggest that calcium channel activators reveal two modes of spasmogenic action for αi-adrenoceptor agonists. Furthermore, we have shown that there may be multiple drug recognition sites on the αi-receptor.
Original language | English |
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Pages (from-to) | 176-184 |
Number of pages | 9 |
Journal | Pharmacology |
Volume | 39 |
Issue number | 3 |
DOIs | |
State | Published - 1989 |
Keywords
- Alpha receptor
- BAY K 8644
- Calcium channel activators
ASJC Scopus subject areas
- Pharmacology