Effects of calcium channel activators on the response of rabbit aortic rings to alpha1-receptor agonists: Evidence for two modes of action

Michael Babich; Brent T. Butler; Michael T. Piascik

doi:10.1159/000138595

Effects of calcium channel activators on the response of rabbit aortic rings to alpha₁-receptor agonists: Evidence for two modes of action

Michael Babich, Brent T. Butler, Michael T. Piascik

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The interaction between activators of the calcium channel and the α_i-radreno-ceptor has been studied in isolated rabbit aortic rings. The data obtained in these investigations are not consistent with the idea of a homogenous population of α_i-receptors which trigger contraction via a single pathway. Our results suggest that calcium channel activators reveal two modes of spasmogenic action for α_i-adrenoceptor agonists. Furthermore, we have shown that there may be multiple drug recognition sites on the α_i-receptor.

Original language	English
Pages (from-to)	176-184
Number of pages	9
Journal	Pharmacology
Volume	39
Issue number	3
DOIs	https://doi.org/10.1159/000138595
State	Published - 1989

Keywords

Alpha receptor
BAY K 8644
Calcium channel activators

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1159/000138595

Cite this

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abstract = "The interaction between activators of the calcium channel and the αi-radreno-ceptor has been studied in isolated rabbit aortic rings. The data obtained in these investigations are not consistent with the idea of a homogenous population of αi-receptors which trigger contraction via a single pathway. Our results suggest that calcium channel activators reveal two modes of spasmogenic action for αi-adrenoceptor agonists. Furthermore, we have shown that there may be multiple drug recognition sites on the αi-receptor.",

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