Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain

M. Hawkins; M. M. Dugich; N. M. Porter; M. Urbancic; M. Radulovacki

doi:10.1016/0361-9230(88)90162-1

Effects of chronic administration of caffeine on adenosine A₁ and A₂ receptors in rat brain

M. Hawkins, M. M. Dugich, N. M. Porter, M. Urbancic, M. Radulovacki

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Chronic administration of caffeine (75 mg/kg/day) to rats for 12 days increased [³H]R-PIA binding in the cerebral cortex and cerebellum and [³H]NECA binding to high affinity receptor sites in the striatum. The results indicate that both adenosine A₁ and A₂ receptor subtypes possess mechanisms of adaptation to chronic caffeine treatment. In addition, adenosine A₁ receptor binding shows heterogenous neuroanatomical pattern indicating that the A, response to caffeine treatment presents regional variation in the rat brain.

Original language	English
Pages (from-to)	479-482
Number of pages	4
Journal	Brain Research Bulletin
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/0361-9230(88)90162-1
State	Published - Sep 1988

Bibliographical note

Funding Information:
This research was supported by FED-AFOSR

Keywords

A and A receptors
Brain
Caffeine-adenosine
Rat

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0361-9230(88)90162-1

Cite this

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title = "Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain",

abstract = "Chronic administration of caffeine (75 mg/kg/day) to rats for 12 days increased [3H]R-PIA binding in the cerebral cortex and cerebellum and [3H]NECA binding to high affinity receptor sites in the striatum. The results indicate that both adenosine A1 and A2 receptor subtypes possess mechanisms of adaptation to chronic caffeine treatment. In addition, adenosine A1 receptor binding shows heterogenous neuroanatomical pattern indicating that the A, response to caffeine treatment presents regional variation in the rat brain.",

keywords = "A and A receptors, Brain, Caffeine-adenosine, Rat",

author = "M. Hawkins and Dugich, {M. M.} and Porter, {N. M.} and M. Urbancic and M. Radulovacki",

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year = "1988",

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T1 - Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain

AU - Hawkins, M.

AU - Dugich, M. M.

AU - Porter, N. M.

AU - Urbancic, M.

AU - Radulovacki, M.

N1 - Funding Information: This research was supported by FED-AFOSR

PY - 1988/9

Y1 - 1988/9

N2 - Chronic administration of caffeine (75 mg/kg/day) to rats for 12 days increased [3H]R-PIA binding in the cerebral cortex and cerebellum and [3H]NECA binding to high affinity receptor sites in the striatum. The results indicate that both adenosine A1 and A2 receptor subtypes possess mechanisms of adaptation to chronic caffeine treatment. In addition, adenosine A1 receptor binding shows heterogenous neuroanatomical pattern indicating that the A, response to caffeine treatment presents regional variation in the rat brain.

AB - Chronic administration of caffeine (75 mg/kg/day) to rats for 12 days increased [3H]R-PIA binding in the cerebral cortex and cerebellum and [3H]NECA binding to high affinity receptor sites in the striatum. The results indicate that both adenosine A1 and A2 receptor subtypes possess mechanisms of adaptation to chronic caffeine treatment. In addition, adenosine A1 receptor binding shows heterogenous neuroanatomical pattern indicating that the A, response to caffeine treatment presents regional variation in the rat brain.

KW - A and A receptors

KW - Brain

KW - Caffeine-adenosine

KW - Rat

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