Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain

M. Hawkins; M. M. Dugich; N. M. Porter; M. Urbancic; M. Radulovacki

doi:10.1016/0361-9230(88)90162-1

Effects of chronic administration of caffeine on adenosine A₁ and A₂ receptors in rat brain

M. Hawkins
, M. M. Dugich
, N. M. Porter
, M. Urbancic
, M. Radulovacki

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Chronic administration of caffeine (75 mg/kg/day) to rats for 12 days increased [³H]R-PIA binding in the cerebral cortex and cerebellum and [³H]NECA binding to high affinity receptor sites in the striatum. The results indicate that both adenosine A₁ and A₂ receptor subtypes possess mechanisms of adaptation to chronic caffeine treatment. In addition, adenosine A₁ receptor binding shows heterogenous neuroanatomical pattern indicating that the A, response to caffeine treatment presents regional variation in the rat brain.

Original language	English
Pages (from-to)	479-482
Number of pages	4
Journal	Brain Research Bulletin
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/0361-9230(88)90162-1
State	Published - Sep 1988

Bibliographical note

Funding Information:
This research was supported by FED-AFOSR

Funding

This research was supported by FED-AFOSR

Funders
FED-AFOSR

Keywords

A and A receptors
Brain
Caffeine-adenosine
Rat

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0361-9230(88)90162-1

Cite this

@article{391614fde0a541e5b712d3072a4ec71f,

title = "Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain",

abstract = "Chronic administration of caffeine (75 mg/kg/day) to rats for 12 days increased [3H]R-PIA binding in the cerebral cortex and cerebellum and [3H]NECA binding to high affinity receptor sites in the striatum. The results indicate that both adenosine A1 and A2 receptor subtypes possess mechanisms of adaptation to chronic caffeine treatment. In addition, adenosine A1 receptor binding shows heterogenous neuroanatomical pattern indicating that the A, response to caffeine treatment presents regional variation in the rat brain.",

keywords = "A and A receptors, Brain, Caffeine-adenosine, Rat",

author = "M. Hawkins and Dugich, \{M. M.\} and Porter, \{N. M.\} and M. Urbancic and M. Radulovacki",

note = "Funding Information: This research was supported by FED-AFOSR",

year = "1988",

month = sep,

doi = "10.1016/0361-9230(88)90162-1",

language = "English",

volume = "21",

pages = "479--482",

number = "3",

}

TY - JOUR

T1 - Effects of chronic administration of caffeine on adenosine A1 and A2 receptors in rat brain

AU - Hawkins, M.

AU - Dugich, M. M.

AU - Porter, N. M.

AU - Urbancic, M.

AU - Radulovacki, M.

N1 - Funding Information: This research was supported by FED-AFOSR

PY - 1988/9

Y1 - 1988/9

N2 - Chronic administration of caffeine (75 mg/kg/day) to rats for 12 days increased [3H]R-PIA binding in the cerebral cortex and cerebellum and [3H]NECA binding to high affinity receptor sites in the striatum. The results indicate that both adenosine A1 and A2 receptor subtypes possess mechanisms of adaptation to chronic caffeine treatment. In addition, adenosine A1 receptor binding shows heterogenous neuroanatomical pattern indicating that the A, response to caffeine treatment presents regional variation in the rat brain.

AB - Chronic administration of caffeine (75 mg/kg/day) to rats for 12 days increased [3H]R-PIA binding in the cerebral cortex and cerebellum and [3H]NECA binding to high affinity receptor sites in the striatum. The results indicate that both adenosine A1 and A2 receptor subtypes possess mechanisms of adaptation to chronic caffeine treatment. In addition, adenosine A1 receptor binding shows heterogenous neuroanatomical pattern indicating that the A, response to caffeine treatment presents regional variation in the rat brain.

KW - A and A receptors

KW - Brain

KW - Caffeine-adenosine

KW - Rat

UR - https://www.scopus.com/pages/publications/0024159449

UR - https://www.scopus.com/pages/publications/0024159449#tab=citedBy

U2 - 10.1016/0361-9230(88)90162-1

DO - 10.1016/0361-9230(88)90162-1

M3 - Article

C2 - 3214753

AN - SCOPUS:0024159449

SN - 0361-9230

VL - 21

SP - 479

EP - 482

JO - Brain Research Bulletin

JF - Brain Research Bulletin

IS - 3

ER -