Effects of chronic oral administration of l-deprenyl in the dog

N. W. Milgram, G. O. Ivy, M. P. Murphy, E. Head, P. H. Wu, W. W. Ruehl, P. H. Yu, D. A. Durden, B. A. Davis, A. A. Boulton

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Dogs were administered capsules containing l-deprenyl daily over 3 weeks at dose levels of 0, 0.1, 0.5, and 1.0 mg/kg. Spontaneous behavior was measured using a canine open field test, and was not significantly affected by l-deprenyl. Plasma levels of amphetamine showed a clear dose-dependent elevation 2 h following treatment, but were markedly lower after 24 h, and were undetectable 5 days following the last treatment. Plasma levels of phenylethylamine were increased, but were highly variable. Animals sacrificed 1 day following the last treatment showed a dose-dependent inhibition of monoamine oxidase B in the brain, liver, and kidney, whereas monoamine oxidase A was unaffected in these tissues. l-Deprenyl also caused an increase in phenylethylamine in the striatum and hypothalamus, but not in the neocortex. Brain levels of DA, DOPAC, 3-MT, HVA, 5-HT, and 5-HIAA were unaffected. The pharmacological profile for the dog is distinct from that of other species in that long-term treatment did not produce any significant inhibition of MAO-A activity. The absence of an effect on biogenic amines or metabolites suggests that the metabolism of dopamine is mediated at least in part through pathways other than MAO-B in the normal adult dog.

Original languageEnglish
Pages (from-to)421-428
Number of pages8
JournalPharmacology Biochemistry and Behavior
Issue number2-3
StatePublished - 1995


  • Amphetamine
  • Dog
  • Monoamine metabolites
  • Monoamine oxidase A
  • Monoamine oxidase B
  • Monoamines
  • Phenylethylamine
  • l-Deprenyl

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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