Effects of d-amphetamine on aggressive responding of normal male subjects

Don R. Cherek, Joel L. Steinberg, Thomas H. Kelly, Dean Robinson

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Male research subjects were administered placebo and three doses of d-amphetamine (5, 10, and 20 mg/70 kg of body weight) under double-blind conditions in a laboratory situation that provided both aggressive and nonaggressive response options. The nonaggressive response was button pressing maintained by the presentation of points which were exchanged for money. The aggressive response was button pressing on a separate manipulandum which ostensibly subtracted points from a fictitious person. Aggressive responding was initially established by subtracting points from the research subjects, which was attributed to the other person. d-Amphetamine increased nonaggressive responding, while aggressive responding was generally decreased.

Original languageEnglish
Pages (from-to)257-265
Number of pages9
JournalPsychiatry Research
Issue number3
StatePublished - Jul 1987

Bibliographical note

Funding Information:
Acknowledgments. The authors thank Steve Mathews for his expert technical assistance. This research was supported by a grant from the National Institute on Drug Abuse (NIDA), DA-03 166. Thomas H. Kelly was supported by a NIDA postdoctoral fellowship, DA-05277.


  • Aggressive behavior
  • d-amphetamine
  • human
  • laboratory
  • normal

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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