Effects of d-amphetamine on behavioral control in stimulant abusers: The role of prepotent response tendencies

Mark T. Fillmore, Craig R. Rush, Cecile A. Marczinski

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


The present study examined the effects of d-amphetamine on the ability to execute and inhibit behavior in a context where preliminary information signaled the likelihood that a response should be executed or suppressed. Eight adults (5 men and 3 women) with a history of stimulant abuse performed a cued go no-go task that required quick responses to go targets and suppression of responses to no-go targets. Performance was tested under four oral doses of d-amphetamine, 0 (placebo), 5, 10 and 20 mg, administered double-blind and in mixed order. d-Amphetamine produced a dose-dependent increase in inhibitory failures following invalid go cues and had no effect on inhibitory failures following valid no-go cues. d-Amphetamine had little effect on response execution as measured by reaction time. Subjective and physiological effects of d-amphetamine were also observed. The findings demonstrate that stimulant effects on fundamental aspects of behavioral control can be mediated by environmental cues that alter response tendencies. Identification of environmental conditions in which stimulants are likely to disinhibit behavior could provide insight into mechanisms that underlie the association between long-term stimulant use and poor impulse control.

Original languageEnglish
Pages (from-to)143-152
Number of pages10
JournalDrug and Alcohol Dependence
Issue number2
StatePublished - Aug 20 2003

Bibliographical note

Funding Information:
This research was supported by grants DA14079 and DA10325 from the National Institute on Drug Abuse and by grant AA12895 from the National Institute on Alcohol Abuse and Alcoholism. Offprint requests should be sent to Mark T. Fillmore, Ph.D., Department of Psychology, University of Kentucky, Lexington, KY 40506-0044. E-mail: [email protected].


  • Human
  • Response inhibition
  • d-Amphetamine

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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