Effects of electroconvulsive shock and brain stimulation on EEG cortical theta rhythms in rats

Philip W. Landfield, James L. McGaugh

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Previous experiments have shown that in rats posttrial electroconvulsive shock treatments impair retention, whereas posttrial mesencephalic reticular stimulation facilitates retention. This experiment examined the effects of electroconvulsive shock (ECS) and low-intensity electrical stimulation of reticular formation on electrocorticographic (ECoG) patterns in rats for a period of 15 min following the ECS treatment. ECS decreased the amount of theta activity (4 to 9 Hz) rhythm recorded from cortical electrodes. Stimulation of the mesencephalic reticular formation following an ECS treatment enhanced ECoG theta rhythm activity. Thus the effects of these treatments on theta activity appear to parallel their effects on memory.

Original languageEnglish
Pages (from-to)271-278
Number of pages8
JournalBehavioral Biology
Issue number2
StatePublished - Apr 1972

Bibliographical note

Funding Information:
Evidence from several recent studies suggests that the degree of retrograde amnesia produced by a disrupting treatment can be attenuated if an 1This research was supported by Research Grant MH 12526 to J. L. McG. and Predoctoral Fellowship No. 1 FO1 MH 45374-01 to P. W. L., from the National Institute of Mental Health, United States Public Health Service, and Biomedical Sciences Support Grant No. US PHS RR-07008-05 from the National Institutes of Health, United States Public Health Service. We thank Edward Scott and Ronald Tusa for technical assistance. 2present address: Laboratory of Chemical Neurobiology, School of Medicine, University of North Carolina, Chapel Hill, N.C. 27514.

ASJC Scopus subject areas

  • Environmental Science (all)
  • Earth and Planetary Sciences (all)


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