TY - JOUR
T1 - Effects of Escherichia coli heat-stable enterotoxin ST(b) on intestines of mice, rats, rabbits, and piglets
AU - Kennedy, Donald J.
AU - Greenberg, Richard N.
AU - Dunn, John A.
AU - Abernathy, Roy
AU - Ryerse, Jan S.
AU - Guerrant, Richard L.
PY - 1984
Y1 - 1984
N2 - There are at least two classes of Escherichia coli heat-stable enterotoxins, ST(a) and ST(b). Unlike ST(a), which is active in suckling mice and piglets, ST(b) is inactive in suckling mice but active in piglets and older, weaned pigs. This study examined the activity of ST(b) in several animals and its effect on intestinal histology and cyclic GMP levels in intestinal mucosal cells. ST(b) did not cause fluid secretion in suckling mice up to 12 days old or in rat or rabbit intestinal-loop preparations. ST(b)-induced fluid secretion in weaned-pig intestinal loops occurred by 30 min and became maximal by 3 to 6 h. ST(b) did not disrupt intestinal histology and did not alter cyclic GMP levels in intestinal mucosal cells from piglet intestinal loops after 0.5- and 6-h incubations. Our studies support the concept that ST(b) is a second heat-stable E. coli enterotoxin with properties and a mechanism of action unlike those of ST(a).
AB - There are at least two classes of Escherichia coli heat-stable enterotoxins, ST(a) and ST(b). Unlike ST(a), which is active in suckling mice and piglets, ST(b) is inactive in suckling mice but active in piglets and older, weaned pigs. This study examined the activity of ST(b) in several animals and its effect on intestinal histology and cyclic GMP levels in intestinal mucosal cells. ST(b) did not cause fluid secretion in suckling mice up to 12 days old or in rat or rabbit intestinal-loop preparations. ST(b)-induced fluid secretion in weaned-pig intestinal loops occurred by 30 min and became maximal by 3 to 6 h. ST(b) did not disrupt intestinal histology and did not alter cyclic GMP levels in intestinal mucosal cells from piglet intestinal loops after 0.5- and 6-h incubations. Our studies support the concept that ST(b) is a second heat-stable E. coli enterotoxin with properties and a mechanism of action unlike those of ST(a).
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U2 - 10.1128/iai.46.3.639-643.1984
DO - 10.1128/iai.46.3.639-643.1984
M3 - Article
C2 - 6094354
AN - SCOPUS:0021682818
SN - 0019-9567
VL - 46
SP - 639
EP - 643
JO - Infection and Immunity
JF - Infection and Immunity
IS - 3
ER -
