Abstract
We studied the effects of gonadol steroid implants on catecholamine levels in the brain of ovariectomized female toadfish (Opsanus tau L.). Control values for dopamine (DA), norepinephrine (NE) and epinephrine (EPI) in the brain were 2181 ± 226, 1112 ± 80 and 6.5 ± 2.02 ng/g, respectively. Compared to controls, 17β-estradiol decreased brain levels of DA to 547 ± 261, and dihydrotestosterone decreased DA to 444 ± 290 ng/g (P < 0.001). Furthermore, dihydrotestosterone increased brain levels of EPI to 15.0 ± 4.7 ng/g. The steroids had no effect on brain levels of NE. These results suggest a role for both androgens and estrogens in regulating brain levels of DA and EPI in toadfish.
| Original language | English |
|---|---|
| Pages (from-to) | 203-206 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 9 1985 |
Bibliographical note
Funding Information:This work was supported by NIH Grants AM31882 and MH389921 and a Virginia Commonwealth University Biomedical Grant-in-Aid. We thank John Althaus of the University of Virginia for assistance with the catecholamine assays.
Funding
This work was supported by NIH Grants AM31882 and MH389921 and a Virginia Commonwealth University Biomedical Grant-in-Aid. We thank John Althaus of the University of Virginia for assistance with the catecholamine assays.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | AM31882, MH389921 |
| Virginia Commonwealth University |
Keywords
- dihydrotestosterone
- dopamine
- epinephrine
- estradiol
- norepinephrine
- testosterone
- toadfish
ASJC Scopus subject areas
- General Neuroscience