Effects of gonadal steroids on catecholamine levels in the brain of the oyster toadfish

Keith R. Pennypacker, Michael L. Fine, Jennifer K. Stewart

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We studied the effects of gonadol steroid implants on catecholamine levels in the brain of ovariectomized female toadfish (Opsanus tau L.). Control values for dopamine (DA), norepinephrine (NE) and epinephrine (EPI) in the brain were 2181 ± 226, 1112 ± 80 and 6.5 ± 2.02 ng/g, respectively. Compared to controls, 17β-estradiol decreased brain levels of DA to 547 ± 261, and dihydrotestosterone decreased DA to 444 ± 290 ng/g (P < 0.001). Furthermore, dihydrotestosterone increased brain levels of EPI to 15.0 ± 4.7 ng/g. The steroids had no effect on brain levels of NE. These results suggest a role for both androgens and estrogens in regulating brain levels of DA and EPI in toadfish.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalNeuroscience Letters
Issue number2
StatePublished - Apr 9 1985

Bibliographical note

Funding Information:
This work was supported by NIH Grants AM31882 and MH389921 and a Virginia Commonwealth University Biomedical Grant-in-Aid. We thank John Althaus of the University of Virginia for assistance with the catecholamine assays.


  • dihydrotestosterone
  • dopamine
  • epinephrine
  • estradiol
  • norepinephrine
  • testosterone
  • toadfish

ASJC Scopus subject areas

  • Neuroscience (all)


Dive into the research topics of 'Effects of gonadal steroids on catecholamine levels in the brain of the oyster toadfish'. Together they form a unique fingerprint.

Cite this