Abstract
This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to determine the effects of grapes and grape products on inflammation and oxidative stress among adults. PubMed, Scopus, ISI Web of Science, and Cochrane Library databases were searched up to July 2020 to identify RCTs investigating the effects of grape and grape products on inflammatory and oxidative stress markers. Weighted mean differences (WMD) were pooled using a random-effects model. Of the 8,962 identified studies, 24 RCTs (27 arms) were included in the statistical analysis. Grape products significantly reduced serum C-reactive protein (CRP) levels (WMD: -0.35 mg/L; 95% CI: -0.62, -0.09, p = .008), but they had no significant effect on serum tumor necrosis factor-alpha (TNF-α) (WMD = -1.08 pg/ml; 95% CI: -2.29, 0.11, p = .07), interleukin-6 (IL-6) (WMD = 0.13 pg/ml; 95% CI: -0.35, 0.60, p = .60), total antioxidant capacity (TAC) (WMD = 0.15; 95% CI: -0.35, 0.65, p = .54), or malondialdehyde (MDA) (WMD = 0.14; 95% CI: -0.64, 0.92, p = .72). The analysis indicated possible decreasing effects of grapes and grape products on CRP, but they might not be able to change IL-6, TNF-α, TAC, and MDA concentrations. Nonetheless, further studies are warranted before definitive conclusions may be reached.
Original language | English |
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Pages (from-to) | 4898-4912 |
Number of pages | 15 |
Journal | Phytotherapy Research |
Volume | 35 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2021 |
Bibliographical note
© 2021 John Wiley & Sons Ltd.Keywords
- Adult
- Antioxidants/metabolism
- Biomarkers/metabolism
- Cytokines/metabolism
- Dietary Supplements
- Humans
- Inflammation/drug therapy
- Oxidative Stress/drug effects
- Phytochemicals/therapeutic use
- Randomized Controlled Trials as Topic
- Vitis/chemistry