Effects of H2O and D2O on polyproline II helical structure

Brian W. Chellgren; Trevor P. Creamer

doi:10.1021/ja045425q

Effects of H₂O and D₂O on polyproline II helical structure

Brian W. Chellgren, Trevor P. Creamer

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The interaction of solvent with a polypeptide chain is one of the primary factors controlling protein folding and stability. In biologically relevant systems, this solvent is most often water. Experimental estimates of the role of water in peptide folding can be obtained from solvent perturbation experiments. The simplest perturbant for H₂O water is its isotopic D₂O form. The solvation of peptides known to form P_II helices with D₂O versus H₂O increases their propensity to adopt the P_II conformation.

Original language	English
Pages (from-to)	14734-14735
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	45
DOIs	https://doi.org/10.1021/ja045425q
State	Published - Nov 17 2004

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja045425q

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abstract = "The interaction of solvent with a polypeptide chain is one of the primary factors controlling protein folding and stability. In biologically relevant systems, this solvent is most often water. Experimental estimates of the role of water in peptide folding can be obtained from solvent perturbation experiments. The simplest perturbant for H2O water is its isotopic D2O form. The solvation of peptides known to form PII helices with D2O versus H2O increases their propensity to adopt the PII conformation.",

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AU - Creamer, Trevor P.

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AB - The interaction of solvent with a polypeptide chain is one of the primary factors controlling protein folding and stability. In biologically relevant systems, this solvent is most often water. Experimental estimates of the role of water in peptide folding can be obtained from solvent perturbation experiments. The simplest perturbant for H2O water is its isotopic D2O form. The solvation of peptides known to form PII helices with D2O versus H2O increases their propensity to adopt the PII conformation.

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JO - Journal of the American Chemical Society

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Effects of H₂O and D₂O on polyproline II helical structure

Abstract

ASJC Scopus subject areas

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