Effects of ibuprofen on a porcine model of acute respiratory failure

Richard Kopolovic, Kathryn M. Thrailkill, Daniel T. Martin, Thomas Ambrose, Michael Vento, Larry C. Carey, Charles T. Cloutier

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Blockade of the arachidonic acid cascade has been shown to improve survival and hemodynamic alterations in animal models of sepsis and acute respiratory failure (ARF). The effects of intravenous ibuprofen, a cyclooxygenase inhibitor, were observed in 20-30 kg pigs with ARF induced by a continuous LD100 infusion of live Pseudomonas aeruginosa (2 × 108/20 kg/min). Cardiopulmonary parameters were monitored in animals intubated, paralyzed, and ventilated at a 250-ml tidal volume and 0.5 FiO2. Pigs were randomly assigned to three groups: Group I received 2 bolus infusions of ibuprofen (12.5 mg/kg) at 20 and 210 min after baseline; Group II had Ps. aeruginosa (2 × 108 CFU/20 kg/min) only; Group III received Ps. aeruginosa and 12.5 mg/kg of ibuprofen at 20 and 210 min of ARF. Ibuprofen alone caused no significant changes in cardiorespiratory parameters. With Ps. aeruginosa infusion, significant pulmonary hypertension, hypoxemia, increased intrapulmonary shunt fraction, and systemic hypotension occurred. In the septic animals treated with ibuprofen, oxygenation was improved by a significant decrease in shunt, pulmonary edema, and pulmonary hypertension.

Original languageEnglish
Pages (from-to)300-305
Number of pages6
JournalJournal of Surgical Research
Volume36
Issue number4
DOIs
StatePublished - Apr 1984

Bibliographical note

Funding Information:
’ Supported in part by the William Ohio State University College of Medicine Company, Kalamazoo, Mich.

ASJC Scopus subject areas

  • Surgery

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