TY - JOUR
T1 - Effects of Long-term Therapy With Calcitriol in Patients With Moderate Renal Failure
AU - Healy, Michael D.
AU - Malluche, Hartmut H.
AU - Goldstein, David A.
AU - Singer, Frederick R.
AU - Massry, Shaul G.
PY - 1980/8
Y1 - 1980/8
N2 - Since abnormalities in divalent ion metabolism occur early in renal insufficiency, treatment of patients with moderate renal failure with calcitriol could halt and/or reverse these disturbances. The effects of long-term treatment with calcitriol (0.5 μ/day) in three such patients were evaluated. Serum calcium level rose from 0.3 to 0.7 mg/dL. Blood parathyroid hormone levels were mildly elevated and fell to normal. Intestinal absorption of calcium increased. The patients had hypocalciuria and the urinary calcium level increased. Creatinine clearance remained stable in all patients. Iliac crest biopsy specimens obtained after double tetracycline hydrochloride labeling revealed mild osteomalacia and hyperparathyroid bone disease that healed after therapy. The data show that a small dose of calcitriol is safe and effective for the management of the derangements of divalent ion metabolism in patients with moderate renal failure.
AB - Since abnormalities in divalent ion metabolism occur early in renal insufficiency, treatment of patients with moderate renal failure with calcitriol could halt and/or reverse these disturbances. The effects of long-term treatment with calcitriol (0.5 μ/day) in three such patients were evaluated. Serum calcium level rose from 0.3 to 0.7 mg/dL. Blood parathyroid hormone levels were mildly elevated and fell to normal. Intestinal absorption of calcium increased. The patients had hypocalciuria and the urinary calcium level increased. Creatinine clearance remained stable in all patients. Iliac crest biopsy specimens obtained after double tetracycline hydrochloride labeling revealed mild osteomalacia and hyperparathyroid bone disease that healed after therapy. The data show that a small dose of calcitriol is safe and effective for the management of the derangements of divalent ion metabolism in patients with moderate renal failure.
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U2 - 10.1001/archinte.1980.00330190042017
DO - 10.1001/archinte.1980.00330190042017
M3 - Article
C2 - 6893118
AN - SCOPUS:84943125037
SN - 0003-9926
VL - 140
SP - 1030
EP - 1033
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 8
ER -