TY - JOUR
T1 - Effects of maternal controlled exercise on offspring adiposity and glucose tolerance
AU - Platt, Kristen M.
AU - Przybylowski, Jenna
AU - Charnigo, Richard J.
AU - Tenlep, Sara Y.Ngo
AU - Reynolds, Leryn J.
AU - Pearson, Kevin J.
N1 - Publisher Copyright:
©
PY - 2022/8/10
Y1 - 2022/8/10
N2 - While metabolic disorders such as obesity and diabetes are costly and deadly to the current population, they are also extremely detrimental to the next generation. Much of the current literature focuses on the negative impact of poor maternal choices on offspring disease, while there is little work examining maternal behaviors that may improve offspring health. Research has shown that voluntary maternal exercise in mouse models improves metabolic function in offspring. In this study, we hypothesized that controlled maternal exercise in a mouse model will effect positive change on offspring obesity and glucose homeostasis. Female mice were separated into three groups: home cage, sedentary, and exercise. The sedentary home cage group was not removed from the home cage, while the sedentary wheel group was removed from the cage and placed in an immobile wheel apparatus. The exercise group was removed from the home cage and run on the same wheel apparatus but with the motor activated at 5-10 m/min for 1 h/d prior to and during pregnancy. Offspring were subjected to oral glucose tolerance testing and body composition analysis. There was no significant difference in offspring glucose tolerance or body composition as a consequence of the maternal exercise intervention compared to the sedentary wheel group. There were no marked negative consequences of the maternal controlled exercise intervention. Further research should clarify the potential advantages of the controlled exercise model and improve experimental techniques to facilitate translation of this research to human applications.
AB - While metabolic disorders such as obesity and diabetes are costly and deadly to the current population, they are also extremely detrimental to the next generation. Much of the current literature focuses on the negative impact of poor maternal choices on offspring disease, while there is little work examining maternal behaviors that may improve offspring health. Research has shown that voluntary maternal exercise in mouse models improves metabolic function in offspring. In this study, we hypothesized that controlled maternal exercise in a mouse model will effect positive change on offspring obesity and glucose homeostasis. Female mice were separated into three groups: home cage, sedentary, and exercise. The sedentary home cage group was not removed from the home cage, while the sedentary wheel group was removed from the cage and placed in an immobile wheel apparatus. The exercise group was removed from the home cage and run on the same wheel apparatus but with the motor activated at 5-10 m/min for 1 h/d prior to and during pregnancy. Offspring were subjected to oral glucose tolerance testing and body composition analysis. There was no significant difference in offspring glucose tolerance or body composition as a consequence of the maternal exercise intervention compared to the sedentary wheel group. There were no marked negative consequences of the maternal controlled exercise intervention. Further research should clarify the potential advantages of the controlled exercise model and improve experimental techniques to facilitate translation of this research to human applications.
KW - Developmental programming
KW - diabetes
KW - gestation
KW - mouse
KW - obesity
KW - running
UR - http://www.scopus.com/inward/record.url?scp=85114998431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85114998431&partnerID=8YFLogxK
U2 - 10.1017/S2040174421000489
DO - 10.1017/S2040174421000489
M3 - Article
C2 - 34503602
AN - SCOPUS:85114998431
SN - 2040-1744
VL - 13
SP - 455
EP - 462
JO - Journal of Developmental Origins of Health and Disease
JF - Journal of Developmental Origins of Health and Disease
IS - 4
ER -