Effects of mechanical interaction between two rabbit cardiac muscles connected in parallel

V. S. Markhasin, L. V. Nikitina, S. M. Routkevich, L. B. Katsnelson, E. A. Schroder, B. B. Keller

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The hypothesis that myocardium mechanical inhomogeneity produces a substantial effect on mechanical function was tested. Muscle inhomogeneity was studied in isolated papillary muscles or trabeculae excised from rabbit right ventricle and connected in a parallel duplex. Each muscle was placed in a separate perfusion bath. One end of each muscle was fastened to an individual force transducer and the other to the common lever of a servomotor. This arrangement allowed both muscles, being excited independently, to pull jointly a load applied to the lever. Separate electrodes for each perfusion bath allowed to stimulate muscles with a time delay. Tension developed in the individual muscles and their interaction were studied. Developed tension was critically dependent on the timing and sequence of excitation. Using mathematical modeling, patterns of tension distribution experimentally observed in parallel duplexes were simulated. These results suggest that changes both in Ca2+ transients and in the time course of Ca2+-troponin complexion due to the duplexed muscles interaction offset the effect of mechanical inhomogenety.

Original languageEnglish
Pages (from-to)277-301
Number of pages25
JournalGeneral Physiology and Biophysics
Issue number3
StatePublished - Sep 2002


  • Asynchronism
  • Inhomogeneity
  • Mathematical modeling
  • Myocardium

ASJC Scopus subject areas

  • Biophysics
  • Physiology


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