TY - JOUR
T1 - Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity
AU - Magkos, Faidon
AU - Fraterrigo, Gemma
AU - Yoshino, Jun
AU - Luecking, Courtney
AU - Kirbach, Kyleigh
AU - Kelly, Shannon C.
AU - De Las Fuentes, Lisa
AU - He, Songbing
AU - Okunade, Adewole L.
AU - Patterson, Bruce W.
AU - Klein, Samuel
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/4/12
Y1 - 2016/4/12
N2 - Summary Although 5%-10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β cell function, without a concomitant change in systemic or subcutaneous adipose tissue markers of inflammation. Additional weight loss further improved β cell function and insulin sensitivity in muscle and caused stepwise changes in adipose tissue mass, intrahepatic triglyceride content, and adipose tissue expression of genes involved in cholesterol flux, lipid synthesis, extracellular matrix remodeling, and oxidative stress. These results demonstrate that moderate 5% weight loss improves metabolic function in multiple organs simultaneously, and progressive weight loss causes dose-dependent alterations in key adipose tissue biological pathways.
AB - Summary Although 5%-10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β cell function, without a concomitant change in systemic or subcutaneous adipose tissue markers of inflammation. Additional weight loss further improved β cell function and insulin sensitivity in muscle and caused stepwise changes in adipose tissue mass, intrahepatic triglyceride content, and adipose tissue expression of genes involved in cholesterol flux, lipid synthesis, extracellular matrix remodeling, and oxidative stress. These results demonstrate that moderate 5% weight loss improves metabolic function in multiple organs simultaneously, and progressive weight loss causes dose-dependent alterations in key adipose tissue biological pathways.
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U2 - 10.1016/j.cmet.2016.02.005
DO - 10.1016/j.cmet.2016.02.005
M3 - Article
C2 - 26916363
AN - SCOPUS:84963647264
SN - 1550-4131
VL - 23
SP - 591
EP - 601
JO - Cell Metabolism
JF - Cell Metabolism
IS - 4
ER -
