Effects of monovalent cations on (Na+ + K+)-ATPase in rat brain slices

Tai Akera, Richard H. Gubitz, Theodore M. Brody, Thomas Tobin

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The influence of monovalent cations on membrane (Na+ + K+)-ATPase was estimated in vitro in intact cells from the oxygen consumption of rat brain cortical slices. High concentrations of K+, Rb+ or Cs+ stimulated the respiration in the presence of Na+. This stimulation was antagonized by ouabain in a concentration- and time-dependent manner. Additionally, only combinations of monovalent cations, that stimulate (Na+ + K+)-ATPase, increased oxygen consumption, indicating that the stimulated portion of respiration is related to the (Na+ + K+)-ATPase activity. Low concentrations of Rb+ and Cs+, however, failed to affect oxygen consumption. Li+ slightly and transiently stimulated oxygen uptake at low concentrations and inhibited it at higher concentrations. Low concentrations of Tl+ also stimulated respiration in a K+-free medium. However, the inhibitory effects of Tl+ were predominant at higher concentrations or in the presence of K+. Thus, monovalent cations can alter (Na+ + K+)-ATPase activity. While Rb+ and Li+ produce opposite effects on this enzyme system under certain conditions, these actions do not seem to be related to the antidepressant action of Rb+ and the antimanic action of Li+.

Original languageEnglish
Pages (from-to)281-292
Number of pages12
JournalEuropean Journal of Pharmacology
Issue number3
StatePublished - May 1 1979

Bibliographical note

Funding Information:
This work was supported by a National Science Foundation grant, BMS 74-18512 A01, and U.S. Public Health Service grants, HL 16052 from the National Heart, Lung and Blood Institute and DA 01881 from the National Institute on Drug Abuse.


  • Lithium
  • Na, K-ATPase
  • Rubidium
  • Tissue respiration

ASJC Scopus subject areas

  • Pharmacology


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