Effects of posttrial hippocampal stimulation on memory storage and EEG activity

Philip W. Landfield; Ronald J. Tusa; James L. McGaugh

doi:10.1016/S0091-6773(73)80042-2

Effects of posttrial hippocampal stimulation on memory storage and EEG activity

Philip W. Landfield, Ronald J. Tusa, James L. McGaugh

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

These experiments investigated the effect of posttrial electrical stimulation of the hippocampus on learning and EEG activity in rats. Experiment I indicated that 3 min of low-intensity electrical bilateral stimulation of ventral hippocampus (VH) initiated at 5 sec posttrial facilitated learning of one-way active avoidance. Experiment II indicated that posttrial stimulation of VH also facilitated the rats' learning of a discriminated avoidance task. In both experiments, unoperated animals were significantly better than controls implanted with electrodes and the learning of VH-stimulated animals was superior to that of the implanted controls. The results of Experiment II indicated VH stimulation increased theta rhythm activity. The findings are interpreted as suggesting that the electrical stimulation enhanced learning by potentiating posttrial neural processes involved in memory storage.

Original language	English
Pages (from-to)	485-505
Number of pages	21
Journal	Behavioral Biology
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/S0091-6773(73)80042-2
State	Published - Apr 1973

Bibliographical note

Funding Information:
Recent findings indicate that impairment and facilitation of memory can also be produced by treatments, such as electrical stimulation and drugs, administered directly to specific brain regions. Memory impairment has been produced by posttrial stimulation of a number of regions including limbic structures, caudate nucleus, midbrain and cortex (cf. Glickman, 1958; Kesner and Doty, 1968; Mahut, 1962; Shinkman and Kaufman, 1972; Wyers and Deadwyler, 1971; Zornetzer and McGaugh, 1972; Zornetzer, 1972). Facilitation of memory has been produced with drug and electrical stimulation of the mesencephalic reticular formation and hippocampus (Alpern, 1968; Bloch, 1Supported by research grant MH 12526 from the National Institute of Mental Health, United States Public Health Service, Predoctoral fellowship No. 1 F01 MH 45374-01 and Training Grant MH 11095-05 from the National Institute of Mental Health, United States Public Health Service, and Biomedical Sciences Support Grant No. USPHS RR-07008-05 from the National Institutes of Health, United States Public Health Service.

ASJC Scopus subject areas

General Environmental Science
General Earth and Planetary Sciences

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title = "Effects of posttrial hippocampal stimulation on memory storage and EEG activity",

abstract = "These experiments investigated the effect of posttrial electrical stimulation of the hippocampus on learning and EEG activity in rats. Experiment I indicated that 3 min of low-intensity electrical bilateral stimulation of ventral hippocampus (VH) initiated at 5 sec posttrial facilitated learning of one-way active avoidance. Experiment II indicated that posttrial stimulation of VH also facilitated the rats' learning of a discriminated avoidance task. In both experiments, unoperated animals were significantly better than controls implanted with electrodes and the learning of VH-stimulated animals was superior to that of the implanted controls. The results of Experiment II indicated VH stimulation increased theta rhythm activity. The findings are interpreted as suggesting that the electrical stimulation enhanced learning by potentiating posttrial neural processes involved in memory storage.",

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note = "Funding Information: Recent findings indicate that impairment and facilitation of memory can also be produced by treatments, such as electrical stimulation and drugs, administered directly to specific brain regions. Memory impairment has been produced by posttrial stimulation of a number of regions including limbic structures, caudate nucleus, midbrain and cortex (cf. Glickman, 1958; Kesner and Doty, 1968; Mahut, 1962; Shinkman and Kaufman, 1972; Wyers and Deadwyler, 1971; Zornetzer and McGaugh, 1972; Zornetzer, 1972). Facilitation of memory has been produced with drug and electrical stimulation of the mesencephalic reticular formation and hippocampus (Alpern, 1968; Bloch, 1Supported by research grant MH 12526 from the National Institute of Mental Health, United States Public Health Service, Predoctoral fellowship No. 1 F01 MH 45374-01 and Training Grant MH 11095-05 from the National Institute of Mental Health, United States Public Health Service, and Biomedical Sciences Support Grant No. USPHS RR-07008-05 from the National Institutes of Health, United States Public Health Service.",

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Effects of posttrial hippocampal stimulation on memory storage and EEG activity

Abstract

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