Abstract
Two experiments were conducted to determine whether methylphenidate or modafinil, two potential pharmacotherapies for stimulant dependence, would impair inhibitory behavior in cocaine users. Eleven cocaine abusers were administered methylphenidate (0, 15, 30, and 45 mg) or modafinil (0, 150, 300, and 450 mg) across four experimental sessions. A cued go-no-go task was used to measure response execution and inhibition. Subjective and cardiovascular measures were collected. Neither methylphenidate nor modafinil impaired inhibitory control, but produced prototypical subject-rated and cardiovascular effects. The results of these studies may have implications for the use of these drugs as agonist-replacement therapies for stimulant dependence.
| Original language | English |
|---|---|
| Pages (from-to) | 293-305 |
| Number of pages | 13 |
| Journal | American Journal of Drug and Alcohol Abuse |
| Volume | 34 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2008 |
Bibliographical note
Funding Information:The authors wish to thank Fran Wagner for her expert nursing assistance and Jamie Haga, Allison Weber, and Bill Stoops for their expert technical assistance. The National Institute on Drug Abuse grant DA 012665 (Dr. Craig Rush) supported this research.
Keywords
- Cocaine
- Inhibition
- Methylphenidate
- Modafinil
- Response
- Stimulants
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Clinical Psychology
- Psychiatry and Mental health
