Effects of rubidium on cardiac tissue: inhibition of Na+,K+ ATPase and stimulation of contractile force

D. Ku, T. Akera, T. Tobin, T. M. Brody

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The effects of rubidium ion on cardiac Na+,K+ adenosine triphosphatase (ATPase) activity and contractile force were studied in guinea pigs. The activity of partially purified cardiac Na+,K+ ATPase preparations was assayed in the presence of 5.8 mM KCl and either 20 or 150 mM aCl. The addition of 2 to 5 mM RbCl significantly inhibited the enzyme activity. In guinea pig left atrial strips, which were stimulated with field electrodes at 1 Hz in a medium containing 5.8 mM KCl and 145 mM NaCl, RbCl produced a dose dependent inotropic response reaching a plateau in 2 min. Propranolol pretreatment failed to alter the Rb+ induced positive inotropic response significantly. These data are consistent with the hypothesis that the inhibition of cardiac Na+, k+ ATPase causes a positive inotropic response.

Original languageEnglish
Pages (from-to)431-440
Number of pages10
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume9
Issue number3
StatePublished - 1974

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics (all)

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