Effects of somatosensory stimulation on use-dependent plasticity in chronic stroke

Lumy Sawaki, Carolyn W.H. Wu, Alain Kaelin-Lang, Leonardo G. Cohen

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Background and Purpose - There is a need to develop strategies to enhance the beneficial effects of motor training, including use-dependent plasticity (UDP), in neurorehabilitation. Peripheral nerve stimulation (PNS) modulates motor cortical excitability in healthy humans and could influence training effects in stroke patients. Methods - We compared the ability of PNS applied to the (1) arm, (2) leg, and (3) idle time to influence training effects in the paretic hand in 7 chronic stroke patients. The end point measure was the magnitude of UDP. Results - UDP was more prominent with arm stimulation (increased by 22.8%) than with idle time (by 2.9%) or leg stimulation (by 6.4%). Conclusions - PNS applied to the paretic limb paired with motor training enhances training effects on cortical plasticity in stroke patients.

Original languageEnglish
Pages (from-to)246-247
Number of pages2
JournalStroke
Volume37
Issue number1
DOIs
StatePublished - Jan 2006

Funding

FundersFunder number
National Institute of Neurological Disorders and StrokeZ01NS003030

    Keywords

    • Nerve stimulation
    • Neuronal plasticity
    • Stimulation
    • Stroke
    • Transcranial magnetic

    ASJC Scopus subject areas

    • Clinical Neurology
    • Cardiology and Cardiovascular Medicine
    • Advanced and Specialized Nursing

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