The aim of the present experiment was to examine the relationship between the discriminative-stimulus and self-reported effects of drugs in humans. To accomplish this aim, nine healthy adult volunteers (four females, five males) were trained to discriminate between placebo and 10 mg d-amphetamine (low-dose group) or 20 mg d-amphetamine (high-dose group). After acquiring the placebo-amphetamine discrimination, a range of doses of d-amphetamine (1.25-20 mg) was tested to determine if they shared discriminative stimulus effects with the training dose. Participants in the low-dose group exhibited a significant leftward shift in the dose-response function for discrimination performance, which is concordant with previous preclinical and human drug discrimination studies that assessed the effects of training dose. Consistent with the drug discrimination findings, participants in the low-dose group exhibited a significant leftward shift in the dose-response function for several self-reported drug effects (e.g., Like the Drug and Stimulated). However, several other self-reported drug effect items were not significantly influenced by training condition (e.g., Anxious/Nervous and Bad Effects). These results suggest that the discriminative-stimulus and self-reported drug effects of d-amphetamine overlap, but are not isomorphic. Furthermore, these results illustrate that behavioral history significantly influences subsequent drug effects in humans. Copyright (C) 1999 Elsevier Science Inc.
|Number of pages||8|
|Journal||Pharmacology Biochemistry and Behavior|
|State||Published - Oct 1999|
Bibliographical noteFunding Information:
This research was supported by funds provided by the University of Mississippi Medical Center School of Medicine and the Department of Psychiatry and Human Behavior, and by the National Institute on Drug Abuse Grant DA 10325 (C.R.R.). The authors are grateful to Richard L. Ogletree Jr., Pharm.D. for preparing the medications, and Catherine A. Hayes for expert technical assistance. Finally, the authors are grateful to Peggy J. Pazzaglia, MD for her expert medical assistance.
- Drug discrimination
- Subjective effects
ASJC Scopus subject areas
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience