Effects of zinc on markers of glutamate and aspartate neurotransmission in rat hippocampus

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38 Scopus citations

Abstract

Receptor binding and synaptosomal uptake of l-[3H]glutamate and l-[3H]aspartate were measured in hippocampus derived from rats maintained on zinc restricted diets from weaning. Despite near lethal zinc deficiency, these markers of excitatory amino acid neurotransmission were unaffected compared to zinc-supplemented controls. However, addition of zinc in vitro markedly inhibited binding of glutamate and aspartate to hippocampal membranes. These data suggest that zinc can modulate the receptor affinities for glutamate and aspartate and may function as a tonic inhibitor of excitatory synapses in vivo.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalBrain Research
Volume334
Issue number2
DOIs
StatePublished - May 20 1985

Keywords

  • aspartate
  • glutamate
  • hippocampus
  • zinc
  • zinc deficiency

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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