Efficacy and safety of a modified oral rehydration solution (ReSoMaL) in the treatment of severely malnourished children with watery diarrhea

N. H. Alam, Jena D. Hamadani, Nahrina Dewan, George J. Fuchs

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Objectives: Efficacy, development of overhydration, and correction of electrolyte disturbances of severely malnourished children with acute diarrhea using a modified oral rehydration solution for malnourished children (termed ReSoMaL and recommended by the World Health Organization [WHO]) were evaluated and compared with standard WHO-oral rehydration solution (ORS). Study design: Children age 6 to 36 months with severe malnutrition and acute watery diarrhea were randomized to ReSoMaL (n = 65) or standard WHO-ORS (n = 65). Major outcome measures included the number of children who developed overhydration and the number who corrected hypokalemia. Results: The numbers of children who developed overhydration were not significantly different (ReSoMaL vs WHO-ORS, 5% vs 12%. P = .2). ReSoMaL corrected basal hypokalemia in a greater proportion of children by 24 hours (36% vs 5%, P = .0006) and 48 hours (46% vs 16%, P = .004) compared with WHO-ORS. More children on ReSoMaL than WHO-ORS remained hyponatremic at 48 hours (29% vs 10%, P = .017). Three children in the ReSoMaL group developed severe hyponatremia by 24 hours, with one experiencing hyponatremic convulsions (serum sodium, 108 mmol/L). Conclusions: ReSoMaL has a large beneficial effect on potassium status compared with standard ORS. However, ReSoMaL therapy may result in symptomatic hyponatremia and seizures in patients with severe diarrhea.

Original languageEnglish
Pages (from-to)614-619
Number of pages6
JournalJournal of Pediatrics
Volume143
Issue number5
DOIs
StatePublished - Nov 2003

Bibliographical note

Funding Information:
Supported by a grant from the World Health Organization (grant no. C6/181/377).

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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