Efficacy of postoperative radiation therapy for recurrent squamous cell carcinoma of the head and neck

William F. Regine, Joseph Valentino, Pushpa Patel, David A. Sloan, Mohammed Mohiuddin, Daniel E. Kenady

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Purpose: Postoperative radiation therapy (RT) following surgical resection is often the recommended treatment for recurrent squamous cell carcinoma (SCC) of the head and neck. Despite common use, there are few published series evaluating such a management approach. Methods and Materials: We evaluated the efficacy of postoperative RT in 31 patients with recurrent SCC of the head and neck treated between 1981 and 1993. None of the patients had prior RT. All had complete resection of recurrent gross disease and no distant metastases. Maximum postoperative RT doses ranged from 59.4-70 Gy (median = 66 Gy). Results: The 5-year disease-specific survival (DSS) and local control (LC) rate for all patients were 32 and 46%, respectively. Several prognostic factors were analyzed including site and stage of original primary tumor, disease-free interval, site of recurrence, status of surgical margins, and dose. Only site of recurrence significantly influenced both DSS and LC. Patients whose recurrence was limited to previously undissected tissue had 5-year DSS and local control rates of 60 and 74%, respectively, as compared to 19 and 29%, respectively, for patients whose recurrence was within previously dissected tissue (p = 0.05). Conclusions: Patients with recurrent SCC of the head and neck treated with standard postoperative RT following surgical resection do relatively well if the recurrence is within previously undissected tissue (i.e., nodal only); however, patients whose recurrence is within previously dissected tissue do poorly. Every effort to prevent loco-regional disease recurrence at the time of primary therapy should be emphasized.

Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume39
Issue number2 SUPPL.
DOIs
StatePublished - 1997

Keywords

  • Head and neck neoplasms
  • Postoperative radiotherapy
  • Recurrent

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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