Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria

Karen F. Novak; William J. Diamond; Sreenatha Kirakodu; Rebecca Peyyala; Kimberly W. Anderson; Ronald C. Montelaro; Timothy A. Mietzner

doi:10.1128/AAC.00924-06

Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria

Karen F. Novak
, William J. Diamond
, Sreenatha Kirakodu
, Rebecca Peyyala
, Kimberly W. Anderson
, Ronald C. Montelaro
, Timothy A. Mietzner

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.

Original language	English
Pages (from-to)	1837-1839
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	5
DOIs	https://doi.org/10.1128/AAC.00924-06
State	Published - May 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.00924-06

Cite this

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title = "Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria",

abstract = "The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.",

author = "Novak, \{Karen F.\} and Diamond, \{William J.\} and Sreenatha Kirakodu and Rebecca Peyyala and Anderson, \{Kimberly W.\} and Montelaro, \{Ronald C.\} and Mietzner, \{Timothy A.\}",

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AU - Novak, Karen F.

AU - Diamond, William J.

AU - Kirakodu, Sreenatha

AU - Peyyala, Rebecca

AU - Anderson, Kimberly W.

AU - Montelaro, Ronald C.

AU - Mietzner, Timothy A.

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Y1 - 2007/5

N2 - The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.

AB - The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.

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UR - https://www.scopus.com/pages/publications/34248386794#tab=citedBy

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AN - SCOPUS:34248386794

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ER -

Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria

Abstract

UN SDGs

ASJC Scopus subject areas

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