EHV-1: A Constant Threat to the Horse Industry

Fatai S. Oladunni, David W. Horohov, Thomas M. Chambers

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations

Abstract

Equine herpesvirus-1 (EHV-1) is one of the most important and prevalent viral pathogens of horses and a major threat to the equine industry throughout most of the world. EHV-1 primarily causes respiratory disease but viral spread to distant organs enables the development of more severe sequelae; abortion and neurologic disease. The virus can also undergo latency during which viral genes are minimally expressed, and reactivate to produce lytic infection at any time. Recently, there has been a trend of increasing numbers of outbreaks of a devastating form of EHV-1, equine herpesviral myeloencephalopathy. This review presents detailed information on EHV-1, from the discovery of the virus to latest developments on treatment and control of the diseases it causes. We also provide updates on recent EHV-1 research with particular emphasis on viral biology which enables pathogenesis in the natural host. The information presented herein will be useful in understanding EHV-1 and formulating policies that would help limit the spread of EHV-1 within horse populations.

Original languageEnglish
Article number2668
JournalFrontiers in Microbiology
Volume10
DOIs
StatePublished - Dec 3 2019

Bibliographical note

Publisher Copyright:
© Copyright © 2019 Oladunni, Horohov and Chambers.

Keywords

  • EHV-1
  • abortion
  • horse
  • latency
  • myeloencephalopathy

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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