Equine herpesvirus-1 (EHV-1) is one of the most important and prevalent viral pathogens of horses and a major threat to the equine industry throughout most of the world. EHV-1 primarily causes respiratory disease but viral spread to distant organs enables the development of more severe sequelae; abortion and neurologic disease. The virus can also undergo latency during which viral genes are minimally expressed, and reactivate to produce lytic infection at any time. Recently, there has been a trend of increasing numbers of outbreaks of a devastating form of EHV-1, equine herpesviral myeloencephalopathy. This review presents detailed information on EHV-1, from the discovery of the virus to latest developments on treatment and control of the diseases it causes. We also provide updates on recent EHV-1 research with particular emphasis on viral biology which enables pathogenesis in the natural host. The information presented herein will be useful in understanding EHV-1 and formulating policies that would help limit the spread of EHV-1 within horse populations.
|Journal||Frontiers in Microbiology|
|State||Published - Dec 3 2019|
Bibliographical noteFunding Information:
FO was supported by grant from the American Quarter Horse Association Young Investigator Award and by a fellowship from the Geoffrey C. Hughes Foundation. This work was supported in part by a grant from the Equine Drug Research Council of the Kentucky Horse Racing Commission. This work is a project of the Kentucky Agricultural Experiment Station (KY014053), supported by the National Institute of Food and Agriculture, U.S. Department of Agriculture, Animal Health Program.
© Copyright © 2019 Oladunni, Horohov and Chambers.
ASJC Scopus subject areas
- Microbiology (medical)