The cerebrospinal fluid (CSF) of 11 premature infants suffering from posthemorrhagic hydrocephalus was examined by radioimmunoassay for prostaglandin (PG) E2, PGF(2α), PGD2, 6-keto PGF(1α), thromboxane B2 (TxB2) and peptidoleukotrienes (LTC4/LTD4). The Lts were detected in the CSF of more of these patients (70%) than any of the other eicosanoids, and usually in the highest concentration. Among the 11 posthemorrhagic patients CSF eicosanoid levels were highest when determined soon after injury. Moreover, the variety of eicosanoids present, as well as concentrations, in these infants decreased with time. The types of eicosanoids most evident in the CSF of patients who required shunting were TxB2 and LTs, being present together in 5 of 6 (83%) of these infants. In contrast, 1 of 5 (20%) of the patients who did not require this neurosurgical intervention contained both TxB2 and LTs, the remaining having only one or neither eicosanoid. The highest average concentration for each eicosanoid studied was (pg/ml): PGE2, 628; PGF(2α), 985, 1410; 6-keto PGF(1α), 544, TxB2, 486 and LTs, 1229. This study is the first to demonstrate that the CSF of preterm infants may contain a wide variety of eicosanoids and indicates that these lipids are a manifestation of neurological assault.
|Number of pages||6|
|Journal||American Journal of the Medical Sciences|
|State||Published - 1990|
Bibliographical noteFunding Information:
From the Departments of Pharmacology, Physiology and Biophysics, Pediatrics, Obstetrics and Gynecology, University of Tennessee Medical Center, Memphis, TN 38163. The authors greatly appreci(lte the technical assistance of J. Giddens, H. Jackson, D. Hardy, T. Nilson and J. Broughton, and the typing skill of Mrs. Marion Johnson. The work was supported in part by USPHS grants NS 21405 and HL 34059 of the National Institutes of Health. Correspondence: Dr. Henrietta S. Bada, Newborn Center, 853 Jefferson Avenue, Rm 201, Pediatrics and OB/GYN, University of Tennessee, Memphis, TN 38163.
- hemorrhagic hydrocephalus
ASJC Scopus subject areas
- Medicine (all)