Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus

R. P. White; C. W. Leffler; H. S. Bada

doi:10.1097/00000441-199004000-00003

Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus

R. P. White, C. W. Leffler, H. S. Bada

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19 Scopus citations

Abstract

The cerebrospinal fluid (CSF) of 11 premature infants suffering from posthemorrhagic hydrocephalus was examined by radioimmunoassay for prostaglandin (PG) E₂, PGF(2α), PGD₂, 6-keto PGF(1α), thromboxane B₂ (TxB₂) and peptidoleukotrienes (LTC₄/LTD₄). The Lts were detected in the CSF of more of these patients (70%) than any of the other eicosanoids, and usually in the highest concentration. Among the 11 posthemorrhagic patients CSF eicosanoid levels were highest when determined soon after injury. Moreover, the variety of eicosanoids present, as well as concentrations, in these infants decreased with time. The types of eicosanoids most evident in the CSF of patients who required shunting were TxB₂ and LTs, being present together in 5 of 6 (83%) of these infants. In contrast, 1 of 5 (20%) of the patients who did not require this neurosurgical intervention contained both TxB₂ and LTs, the remaining having only one or neither eicosanoid. The highest average concentration for each eicosanoid studied was (pg/ml): PGE₂, 628; PGF(2α), 985, 1410; 6-keto PGF(1α), 544, TxB₂, 486 and LTs, 1229. This study is the first to demonstrate that the CSF of preterm infants may contain a wide variety of eicosanoids and indicates that these lipids are a manifestation of neurological assault.

Original language	English
Pages (from-to)	230-235
Number of pages	6
Journal	American Journal of the Medical Sciences
Volume	299
Issue number	4
DOIs	https://doi.org/10.1097/00000441-199004000-00003
State	Published - 1990

Bibliographical note

Funding Information:
From the Departments of Pharmacology, Physiology and Biophysics, Pediatrics, Obstetrics and Gynecology, University of Tennessee Medical Center, Memphis, TN 38163. The authors greatly appreci(lte the technical assistance of J. Giddens, H. Jackson, D. Hardy, T. Nilson and J. Broughton, and the typing skill of Mrs. Marion Johnson. The work was supported in part by USPHS grants NS 21405 and HL 34059 of the National Institutes of Health. Correspondence: Dr. Henrietta S. Bada, Newborn Center, 853 Jefferson Avenue, Rm 201, Pediatrics and OB/GYN, University of Tennessee, Memphis, TN 38163.

Keywords

CSF
eicosanoids
hemorrhagic hydrocephalus

ASJC Scopus subject areas

General Medicine

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10.1097/00000441-199004000-00003

Cite this

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title = "Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus",

abstract = "The cerebrospinal fluid (CSF) of 11 premature infants suffering from posthemorrhagic hydrocephalus was examined by radioimmunoassay for prostaglandin (PG) E2, PGF(2α), PGD2, 6-keto PGF(1α), thromboxane B2 (TxB2) and peptidoleukotrienes (LTC4/LTD4). The Lts were detected in the CSF of more of these patients (70%) than any of the other eicosanoids, and usually in the highest concentration. Among the 11 posthemorrhagic patients CSF eicosanoid levels were highest when determined soon after injury. Moreover, the variety of eicosanoids present, as well as concentrations, in these infants decreased with time. The types of eicosanoids most evident in the CSF of patients who required shunting were TxB2 and LTs, being present together in 5 of 6 (83%) of these infants. In contrast, 1 of 5 (20%) of the patients who did not require this neurosurgical intervention contained both TxB2 and LTs, the remaining having only one or neither eicosanoid. The highest average concentration for each eicosanoid studied was (pg/ml): PGE2, 628; PGF(2α), 985, 1410; 6-keto PGF(1α), 544, TxB2, 486 and LTs, 1229. This study is the first to demonstrate that the CSF of preterm infants may contain a wide variety of eicosanoids and indicates that these lipids are a manifestation of neurological assault.",

keywords = "CSF, eicosanoids, hemorrhagic hydrocephalus",

author = "White, {R. P.} and Leffler, {C. W.} and Bada, {H. S.}",

note = "Funding Information: From the Departments of Pharmacology, Physiology and Biophysics, Pediatrics, Obstetrics and Gynecology, University of Tennessee Medical Center, Memphis, TN 38163. The authors greatly appreci(lte the technical assistance of J. Giddens, H. Jackson, D. Hardy, T. Nilson and J. Broughton, and the typing skill of Mrs. Marion Johnson. The work was supported in part by USPHS grants NS 21405 and HL 34059 of the National Institutes of Health. Correspondence: Dr. Henrietta S. Bada, Newborn Center, 853 Jefferson Avenue, Rm 201, Pediatrics and OB/GYN, University of Tennessee, Memphis, TN 38163.",

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T1 - Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus

AU - White, R. P.

AU - Leffler, C. W.

AU - Bada, H. S.

N1 - Funding Information: From the Departments of Pharmacology, Physiology and Biophysics, Pediatrics, Obstetrics and Gynecology, University of Tennessee Medical Center, Memphis, TN 38163. The authors greatly appreci(lte the technical assistance of J. Giddens, H. Jackson, D. Hardy, T. Nilson and J. Broughton, and the typing skill of Mrs. Marion Johnson. The work was supported in part by USPHS grants NS 21405 and HL 34059 of the National Institutes of Health. Correspondence: Dr. Henrietta S. Bada, Newborn Center, 853 Jefferson Avenue, Rm 201, Pediatrics and OB/GYN, University of Tennessee, Memphis, TN 38163.

PY - 1990

Y1 - 1990

N2 - The cerebrospinal fluid (CSF) of 11 premature infants suffering from posthemorrhagic hydrocephalus was examined by radioimmunoassay for prostaglandin (PG) E2, PGF(2α), PGD2, 6-keto PGF(1α), thromboxane B2 (TxB2) and peptidoleukotrienes (LTC4/LTD4). The Lts were detected in the CSF of more of these patients (70%) than any of the other eicosanoids, and usually in the highest concentration. Among the 11 posthemorrhagic patients CSF eicosanoid levels were highest when determined soon after injury. Moreover, the variety of eicosanoids present, as well as concentrations, in these infants decreased with time. The types of eicosanoids most evident in the CSF of patients who required shunting were TxB2 and LTs, being present together in 5 of 6 (83%) of these infants. In contrast, 1 of 5 (20%) of the patients who did not require this neurosurgical intervention contained both TxB2 and LTs, the remaining having only one or neither eicosanoid. The highest average concentration for each eicosanoid studied was (pg/ml): PGE2, 628; PGF(2α), 985, 1410; 6-keto PGF(1α), 544, TxB2, 486 and LTs, 1229. This study is the first to demonstrate that the CSF of preterm infants may contain a wide variety of eicosanoids and indicates that these lipids are a manifestation of neurological assault.

AB - The cerebrospinal fluid (CSF) of 11 premature infants suffering from posthemorrhagic hydrocephalus was examined by radioimmunoassay for prostaglandin (PG) E2, PGF(2α), PGD2, 6-keto PGF(1α), thromboxane B2 (TxB2) and peptidoleukotrienes (LTC4/LTD4). The Lts were detected in the CSF of more of these patients (70%) than any of the other eicosanoids, and usually in the highest concentration. Among the 11 posthemorrhagic patients CSF eicosanoid levels were highest when determined soon after injury. Moreover, the variety of eicosanoids present, as well as concentrations, in these infants decreased with time. The types of eicosanoids most evident in the CSF of patients who required shunting were TxB2 and LTs, being present together in 5 of 6 (83%) of these infants. In contrast, 1 of 5 (20%) of the patients who did not require this neurosurgical intervention contained both TxB2 and LTs, the remaining having only one or neither eicosanoid. The highest average concentration for each eicosanoid studied was (pg/ml): PGE2, 628; PGF(2α), 985, 1410; 6-keto PGF(1α), 544, TxB2, 486 and LTs, 1229. This study is the first to demonstrate that the CSF of preterm infants may contain a wide variety of eicosanoids and indicates that these lipids are a manifestation of neurological assault.

KW - CSF

KW - eicosanoids

KW - hemorrhagic hydrocephalus

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DO - 10.1097/00000441-199004000-00003

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SN - 0002-9629

VL - 299

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EP - 235

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

IS - 4

ER -

Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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