Electromagnetic field treatment of nerve crush injury in a rat model: Effect of signal configuration on functional recovery

Janet L. Walker, Richard Kryscio, Jennifer Smith, Arthur Pilla, Betty F. Sisken

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Electromagnetic fields (EMFs) have been demonstrated to enhance mammalian peripheral nerve regeneration in vitro and in vivo. Using an EMF signal shown to enhance neurite outgrowth in vitro, we tested this field in vivo using three different amplitudes. The rat sciatic nerve was crushed. Whole body exposure was performed for 4 h/day for 5 days in a 96-turn solenoid coil controlled by a signal generator and power amplifier. The induced electric field at the target tissue consisted of a bipolar rectangular pulse, having 1 and 0.3 ms durations in each polarity, respectively. Pulse repetition rate was 2 per second. By varying the current, the coils produced fields consisting of sham (no current) and peak magnetic fields of 0.03 mT, 0.3 mT, and 3 mT, corresponding to peak induced electric fields of 1, 10, and 100 μV/cm, respectively, at the tissue target. Walking function was assessed over 43 days using video recording and measurement of the 1-5 toe-spread, using an imaging program. Comparing injured to uninjured hind limbs, mean responses were evaluated using a linear mixed statistical model. There was no difference found in recovery of the toe-spread function between any EMF treatments compared to sham.

Original languageEnglish
Pages (from-to)256-263
Number of pages8
Issue number4
StatePublished - May 2007


  • Axonotmesis
  • Footprint analysis
  • Nerve regeneration
  • Therapeutic EMF

ASJC Scopus subject areas

  • Biophysics
  • Physiology
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Electromagnetic field treatment of nerve crush injury in a rat model: Effect of signal configuration on functional recovery'. Together they form a unique fingerprint.

Cite this