TY - JOUR
T1 - Electron bifurcation
AU - Peters, John W.
AU - Miller, Anne Frances
AU - Jones, Anne K.
AU - King, Paul W.
AU - Adams, Michael W.W.
N1 - Publisher Copyright:
© 2016.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Electron bifurcation is the recently recognized third mechanism of biological energy conservation. It simultaneously couples exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss. Little is known about the details of how electron bifurcating enzymes function, but specifics are beginning to emerge for several bifurcating enzymes. To date, those characterized contain a collection of redox cofactors including flavins and iron-sulfur clusters. Here we discuss the current understanding of bifurcating enzymes and the mechanistic features required to reversibly partition multiple electrons from a single redox site into exergonic and endergonic electron transfer paths.
AB - Electron bifurcation is the recently recognized third mechanism of biological energy conservation. It simultaneously couples exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss. Little is known about the details of how electron bifurcating enzymes function, but specifics are beginning to emerge for several bifurcating enzymes. To date, those characterized contain a collection of redox cofactors including flavins and iron-sulfur clusters. Here we discuss the current understanding of bifurcating enzymes and the mechanistic features required to reversibly partition multiple electrons from a single redox site into exergonic and endergonic electron transfer paths.
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U2 - 10.1016/j.cbpa.2016.03.007
DO - 10.1016/j.cbpa.2016.03.007
M3 - Review article
C2 - 27016613
AN - SCOPUS:84962556232
SN - 1367-5931
VL - 31
SP - 146
EP - 152
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
ER -