Electron bifurcation

John W. Peters; Anne Frances Miller; Anne K. Jones; Paul W. King; Michael W.W. Adams

doi:10.1016/j.cbpa.2016.03.007

Electron bifurcation

John W. Peters, Anne Frances Miller, Anne K. Jones, Paul W. King, Michael W.W. Adams

Research output: Contribution to journal › Review article › peer-review

91 Scopus citations

Abstract

Electron bifurcation is the recently recognized third mechanism of biological energy conservation. It simultaneously couples exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss. Little is known about the details of how electron bifurcating enzymes function, but specifics are beginning to emerge for several bifurcating enzymes. To date, those characterized contain a collection of redox cofactors including flavins and iron-sulfur clusters. Here we discuss the current understanding of bifurcating enzymes and the mechanistic features required to reversibly partition multiple electrons from a single redox site into exergonic and endergonic electron transfer paths.

Original language	English
Pages (from-to)	146-152
Number of pages	7
Journal	Current Opinion in Chemical Biology
Volume	31
DOIs	https://doi.org/10.1016/j.cbpa.2016.03.007
State	Published - Apr 1 2016

Bibliographical note

Funding Information:
This work is supported as part of the Biological and Electron Transfer and Catalysis (BETCy) EFRC, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science ( DE-SC0012518 ). P.W.K. was supported by the U.S. Department of Energy under contract no. DE-AC36-08-GO28308 with the National Renewable Energy Laboratory. We thank the entire BETCy team for helpful discussions.

Publisher Copyright:
© 2016.

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cbpa.2016.03.007

Cite this

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abstract = "Electron bifurcation is the recently recognized third mechanism of biological energy conservation. It simultaneously couples exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss. Little is known about the details of how electron bifurcating enzymes function, but specifics are beginning to emerge for several bifurcating enzymes. To date, those characterized contain a collection of redox cofactors including flavins and iron-sulfur clusters. Here we discuss the current understanding of bifurcating enzymes and the mechanistic features required to reversibly partition multiple electrons from a single redox site into exergonic and endergonic electron transfer paths.",

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AU - Miller, Anne Frances

AU - Jones, Anne K.

AU - King, Paul W.

AU - Adams, Michael W.W.

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Y1 - 2016/4/1

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AB - Electron bifurcation is the recently recognized third mechanism of biological energy conservation. It simultaneously couples exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss. Little is known about the details of how electron bifurcating enzymes function, but specifics are beginning to emerge for several bifurcating enzymes. To date, those characterized contain a collection of redox cofactors including flavins and iron-sulfur clusters. Here we discuss the current understanding of bifurcating enzymes and the mechanistic features required to reversibly partition multiple electrons from a single redox site into exergonic and endergonic electron transfer paths.

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Electron bifurcation

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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