An electron capturing derivative of apomorphine was prepared by incubating the drug with heptafluorobutyric anhydride (HFBA), triethylamine and heat. Mass spectral analysis suggests that HFBA reacts with both phenolic hydroxyl groups on apomorphine to give a derivative detectable at low picogram levels. This method is sufficiently sensitive for pharmaco kinetic studies in the horse and is likely applicable to other dopaminergic analogues of apomorphine.
|Number of pages||9|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - 1976|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics (all)