Electron capture detection of an apomorphine heptafluorobutyrate derivative at low picogram levels

J. R. Miller; J. W. Blake; T. Tobin

Electron capture detection of an apomorphine heptafluorobutyrate derivative at low picogram levels

J. R. Miller, J. W. Blake, T. Tobin

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

An electron capturing derivative of apomorphine was prepared by incubating the drug with heptafluorobutyric anhydride (HFBA), triethylamine and heat. Mass spectral analysis suggests that HFBA reacts with both phenolic hydroxyl groups on apomorphine to give a derivative detectable at low picogram levels. This method is sufficiently sensitive for pharmaco kinetic studies in the horse and is likely applicable to other dopaminergic analogues of apomorphine.

Original language	English
Pages (from-to)	447-455
Number of pages	9
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	15
Issue number	3
State	Published - 1976

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pathology and Forensic Medicine
Toxicology
Pharmacology

Cite this

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title = "Electron capture detection of an apomorphine heptafluorobutyrate derivative at low picogram levels",

abstract = "An electron capturing derivative of apomorphine was prepared by incubating the drug with heptafluorobutyric anhydride (HFBA), triethylamine and heat. Mass spectral analysis suggests that HFBA reacts with both phenolic hydroxyl groups on apomorphine to give a derivative detectable at low picogram levels. This method is sufficiently sensitive for pharmaco kinetic studies in the horse and is likely applicable to other dopaminergic analogues of apomorphine.",

author = "Miller, {J. R.} and Blake, {J. W.} and T. Tobin",

year = "1976",

language = "English",

volume = "15",

pages = "447--455",

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TY - JOUR

T1 - Electron capture detection of an apomorphine heptafluorobutyrate derivative at low picogram levels

AU - Miller, J. R.

AU - Blake, J. W.

AU - Tobin, T.

PY - 1976

Y1 - 1976

N2 - An electron capturing derivative of apomorphine was prepared by incubating the drug with heptafluorobutyric anhydride (HFBA), triethylamine and heat. Mass spectral analysis suggests that HFBA reacts with both phenolic hydroxyl groups on apomorphine to give a derivative detectable at low picogram levels. This method is sufficiently sensitive for pharmaco kinetic studies in the horse and is likely applicable to other dopaminergic analogues of apomorphine.

AB - An electron capturing derivative of apomorphine was prepared by incubating the drug with heptafluorobutyric anhydride (HFBA), triethylamine and heat. Mass spectral analysis suggests that HFBA reacts with both phenolic hydroxyl groups on apomorphine to give a derivative detectable at low picogram levels. This method is sufficiently sensitive for pharmaco kinetic studies in the horse and is likely applicable to other dopaminergic analogues of apomorphine.

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M3 - Article

C2 - 996359

AN - SCOPUS:0017147343

SN - 0034-5164

VL - 15

SP - 447

EP - 455

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 3

ER -

Electron capture detection of an apomorphine heptafluorobutyrate derivative at low picogram levels

Abstract

ASJC Scopus subject areas

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