Electron capture detection of an apomorphine heptafluorobutyrate derivative at low picogram levels

J. R. Miller, J. W. Blake, T. Tobin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

An electron capturing derivative of apomorphine was prepared by incubating the drug with heptafluorobutyric anhydride (HFBA), triethylamine and heat. Mass spectral analysis suggests that HFBA reacts with both phenolic hydroxyl groups on apomorphine to give a derivative detectable at low picogram levels. This method is sufficiently sensitive for pharmaco kinetic studies in the horse and is likely applicable to other dopaminergic analogues of apomorphine.

Original languageEnglish
Pages (from-to)447-455
Number of pages9
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume15
Issue number3
StatePublished - 1976

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics (all)

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