Abstract
Comparison of electron spin resonance spectra of spin labeled erythrocyte membranes from patients with the dystrophic conditions Duchenne and myotonic muscular dystrophy with those of normal controls suggests that alterations in membrane protein conformation and/or organization are present in these disease states. These protein alterations are not apparent in the nondystrophic disease congenital myotonia. The results suggest a correlation between changes in the physical state of protein in membranes with the presence of dystrophy. In addition, the present results from erythrocytes lend support for the concept of a generalized membrane defect in these diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | BBA - Biomembranes |
| Volume | 470 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 3 1977 |
Bibliographical note
Funding Information:The author wishes to thank Drs. William Markesbery and Robert Egel of the Department of Neurology for help in patientdiagnosis and Drs. Robert Lester and Roger Laine of the Department of Biochemistry for helpful discussions and for making some research facilities available. This work was supported in part by a research grant from the Muscular Dystrophy Association of America, Inc., a Frederick Gardner Cottrell Research Grant from the Research Corporation and funds from the Research Foundation and Graduate School of the University of Kentucky.
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Cell Biology