Chemical investigation of the marine-derived Streptomyces sp. Act8015 led to the isolation of two cyclic peptide antibiotics, piperazimycins A and B (la, lb). Their structures were confirmed on the basis of a detailed HRESI-MS/MS analysis. Additionally, a new butanolide, 4,10-dihydroxy-10-methyl-dodecan-4- olide (2), and the respective acid, 4,10-dihydroxy-10-methyl-dodecanoic acid (3a) were identified. Further isolated compounds were staurosporin, adenine, indole-3-carboxylic acid, ferulic acid, tryptophol, and three y-butyrolactones: virginiae butanolide E (4e) and Graefe's Factors I (4f) and III (4g). The structures of 2 and 3a were confirmed by detailed ID and 2D NMR studies and MS spectra and by comparison with related structures. A full signal assignment of virginiae butanolide E (4e) is reported here for the first time.
|Number of pages||11|
|Journal||Journal of Antibiotics|
|State||Published - Dec 2008|
Bibliographical noteFunding Information:
Acknowledgements We thank Mr. R. Machinek for NMR measurements, F. Lissy for biological activity tests and A. Kohl for technical assistance. P. Facey thanks the Alexander von Humboldt Foundation (AvH) for a research fellowship. Financial support from the BMBF (Project No. 03F0415A) is gratefully acknowledged.
- Marine-derived streptomyces sp
ASJC Scopus subject areas
- Drug Discovery