Elemental imbalance studies by INAA on extraneural tissues from amyotrophic lateral sclerosis patients

L. Tandon, E. J. Kasarskis, W. D. Ehmann

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Human kidney and liver tissues were studied for generalized elemental imbalances in amyotrophic lateral sclerosis (ALS) by instrumental neutron activation analysis (INAA). Iron was significantly increased (p<0.05) in ALS kidneys and Co and Fe (marginal, p<0.10) were increased in ALS liver compared with their respective controls. Mercury values were almost two-fold higher for ALS kidney and 17% higher for ALS liver as compared with their respective controls. However, the Hg data exhibited large variations and ALS-control differences were not significant. Data from the present study are discussed with reference to the role of metallothioneins (MT) in ALS, and a possible linkage between a free radical mediated mechanism and degeneration of cells in ALS is also explored.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalJournal of Radioanalytical and Nuclear Chemistry Articles
Volume195
Issue number1
DOIs
StatePublished - Aug 1995

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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