Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

M. A. Lovell; W. D. Ehmann; M. P. Mattson; W. R. Markesbery

doi:10.1016/S0197-4580(97)00108-5

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

M. A. Lovell, W. D. Ehmann, M. P. Mattson, W. R. Markesbery

Research output: Contribution to journal › Article › peer-review

377 Scopus citations

Abstract

4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD) we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.

Original language	English
Pages (from-to)	457-461
Number of pages	5
Journal	Neurobiology of Aging
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/S0197-4580(97)00108-5
State	Published - Sep 1997

Bibliographical note

Funding Information:
The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason and Brian Hallahan for technical assistance. This work was supported by National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.

Funding

The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason and Brian Hallahan for technical assistance. This work was supported by National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.

Funders	Funder number
National Institutes of Health (NIH)	1-P01-AG05119
National Institute on Aging	P50AG005144
Abercrombie Foundation

Keywords

4-Hydroxynonenal
Alzheimer's disease
Lipid peroxidation
Oxidative stress
Ventricular fluid

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/S0197-4580(97)00108-5

Cite this

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title = "Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease",

abstract = "4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD) we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.",

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note = "Funding Information: The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason and Brian Hallahan for technical assistance. This work was supported by National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.",

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AU - Ehmann, W. D.

AU - Mattson, M. P.

AU - Markesbery, W. R.

N1 - Funding Information: The authors thank Drs. Daron Davis and David Wekstein for patient and ventricular fluid procurement, and Don Rightmyer, Paula Thomason and Brian Hallahan for technical assistance. This work was supported by National Institute of Health Grants 1-P01-AG05119 and 5-P50-AG05144 and a grant from the Abercrombie Foundation.

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N2 - 4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD) we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.

AB - 4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD) we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.

KW - 4-Hydroxynonenal

KW - Alzheimer's disease

KW - Lipid peroxidation

KW - Oxidative stress

KW - Ventricular fluid

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Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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