Elevated basal AP-1 DNA binding activity in developing rat brain

K. R. Pennypacker, Duane Dreyer, J. S. Hong, Michael K. McMillian

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Nuclear extracts from hippocampi, striata and hypothalami of postnatal day (P) 7 rats contained elevated basal levels of AP-1 DNA binding activity and c-jun protein, which decreased to the low basal levels observed in the adult by P21. In contrast to the AP-1 DNA binding complex in the adult brain, the fos-related antigens were not a major component of the P7 AP-1 DNA binding activity.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalMolecular Brain Research
Issue number4
StatePublished - Sep 1993


  • Fos-related antigen
  • Hippocampus
  • Hypothalamus
  • Striatum
  • Transcription factor
  • c-jun

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience


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