Elevated CNS inflammation in patients with preclinical Alzheimer's disease

Nancy L. Monson; Sara J. Ireland; Ann J. Ligocki; Ding Chen; William H. Rounds; Min Li; Ryan M. Huebinger; C. Munro Cullum; Benjamin M. Greenberg; Ann M. Stowe; Rong Zhang

doi:10.1038/jcbfm.2013.183

Elevated CNS inflammation in patients with preclinical Alzheimer's disease

Nancy L. Monson, Sara J. Ireland, Ann J. Ligocki, Ding Chen, William H. Rounds, Min Li, Ryan M. Huebinger, C. Munro Cullum, Benjamin M. Greenberg, Ann M. Stowe, Rong Zhang

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Alzheimer's disease (AD) is a progressive, neurodegenerative disease that may involve inflammatory responses in the central nervous system (CNS). Our objective was to determine whether patients with amnestic mild cognitive impairment (aMCI), a preclinical stage of AD, have inflammatory characteristics similar to patients with multiple sclerosis (MS), a known CNS inflammatory disease. The frequency of lymphocytes and levels of pro-inflammatory cytokines in the cerebrospinal fluid of aMCI patients was comparable to MS patients or patients at high risk to develop MS. Thus, brain inflammation occurs early at the preclinical stage of AD and may have an important role in pathology.

Original language	English
Pages (from-to)	30-33
Number of pages	4
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	34
Issue number	1
DOIs	https://doi.org/10.1038/jcbfm.2013.183
State	Published - Jan 2014

Keywords

Alzheimer's disease
T cells
dementia
inflammation
leukocytes

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/jcbfm.2013.183

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title = "Elevated CNS inflammation in patients with preclinical Alzheimer's disease",

abstract = "Alzheimer's disease (AD) is a progressive, neurodegenerative disease that may involve inflammatory responses in the central nervous system (CNS). Our objective was to determine whether patients with amnestic mild cognitive impairment (aMCI), a preclinical stage of AD, have inflammatory characteristics similar to patients with multiple sclerosis (MS), a known CNS inflammatory disease. The frequency of lymphocytes and levels of pro-inflammatory cytokines in the cerebrospinal fluid of aMCI patients was comparable to MS patients or patients at high risk to develop MS. Thus, brain inflammation occurs early at the preclinical stage of AD and may have an important role in pathology.",

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AU - Ireland, Sara J.

AU - Ligocki, Ann J.

AU - Chen, Ding

AU - Rounds, William H.

AU - Li, Min

AU - Huebinger, Ryan M.

AU - Munro Cullum, C.

AU - Greenberg, Benjamin M.

AU - Stowe, Ann M.

AU - Zhang, Rong

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N2 - Alzheimer's disease (AD) is a progressive, neurodegenerative disease that may involve inflammatory responses in the central nervous system (CNS). Our objective was to determine whether patients with amnestic mild cognitive impairment (aMCI), a preclinical stage of AD, have inflammatory characteristics similar to patients with multiple sclerosis (MS), a known CNS inflammatory disease. The frequency of lymphocytes and levels of pro-inflammatory cytokines in the cerebrospinal fluid of aMCI patients was comparable to MS patients or patients at high risk to develop MS. Thus, brain inflammation occurs early at the preclinical stage of AD and may have an important role in pathology.

AB - Alzheimer's disease (AD) is a progressive, neurodegenerative disease that may involve inflammatory responses in the central nervous system (CNS). Our objective was to determine whether patients with amnestic mild cognitive impairment (aMCI), a preclinical stage of AD, have inflammatory characteristics similar to patients with multiple sclerosis (MS), a known CNS inflammatory disease. The frequency of lymphocytes and levels of pro-inflammatory cytokines in the cerebrospinal fluid of aMCI patients was comparable to MS patients or patients at high risk to develop MS. Thus, brain inflammation occurs early at the preclinical stage of AD and may have an important role in pathology.

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Elevated CNS inflammation in patients with preclinical Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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