Elevated oxidative stress in models of normal brain aging and Alzheimer's disease

D. Allan Butterfield, Beverly Howard, Servet Yatin, Tanuja Koppal, Jennifer Drake, Kenneth Hensley, Michael Aksenov, Marina Aksenova, Ram Subramaniam, Sridhar Varadarajan, Marni E. Harris-White, Norman W. Pedigo, John M. Carney

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

Age-associated neurodegenerative disorders are becoming more prevalent as the mean age of the population increases in the United States over the next few decades. Both normal brain aging and Alzheimer's disease (AD) are associated with oxidative stress. Our laboratory has used a wide variety of physical and biochemical methods to investigate free radical oxidative stress in several models of aging and AD. β-Amyloid (Aβ), the peptide that constitutes the central core of senile plaques in AD brain, is associated with free radical oxidative stress and is toxic to neurons. This review summarizes some of our studies in aging and Aβ-associated free radical oxidative stress and on the modulating effects of free radical scavengers on neocortical synaptosomal membrane damage found in aging and Aβ-treated systems.

Original languageEnglish
Pages (from-to)1883-1892
Number of pages10
JournalLife Sciences
Volume65
Issue number18-19
DOIs
StatePublished - Oct 1 1999

Keywords

  • Aging
  • Alzheimer's disease
  • Free radicals
  • Hydroxynonenal
  • Lipid peroxidation
  • Protein oxidation
  • β-Amyloid

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology

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