Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

D. Allan Butterfield; Tanea Reed; Marzia Perluigi; Carlo De Marco; Raffaella Coccia; Chiara Cini; Rukhsana Sultana

doi:10.1016/j.neulet.2005.12.017

Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

D. Allan Butterfield, Tanea Reed, Marzia Perluigi, Carlo De Marco, Raffaella Coccia, Chiara Cini, Rukhsana Sultana

Research output: Contribution to journal › Article › peer-review

227 Scopus citations

Abstract

Oxidative damage is a feature of many age-related neurodegenerative diseases, including Alzheimer's disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of the free radical-mediated lipid peroxidation of unsaturated lipids, particularly arachidonic acid, in cellular membranes. In the present study we show for the first time in brain obtained at short postmortem intervals that the levels of HNE are elevated in mild cognitive impairment (MCI) hippocampus and inferior parietal lobules compared to those of control brain. Thus, increased levels of HNE in MCI brain implicate lipid peroxidation as an early event in AD pathophysiology and also suggest that the pharmacologic intervention to prevent lipid peroxidation at the MCI stage or earlier may be a promising therapeutic strategy to delay or prevent progression to AD.

Original language	English
Pages (from-to)	170-173
Number of pages	4
Journal	Neuroscience Letters
Volume	397
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2005.12.017
State	Published - Apr 24 2006

Bibliographical note

Funding Information:
The authors would like to thank the University of Kentucky ADRC Clinical Neuropathology Core faculty for providing the brain tissue used for this study. This work was supported in part by NIH grants to D.A.B. [AG-05119; AG-10836].

Keywords

4-Hydroxynonenol
Alzheimer's disease
Hippocampus
Inferior parietal lobule
Lipid peroxidation
Mild cognitive impairment
Oxidative stress

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neulet.2005.12.017

Cite this

@article{9b58bd5fcbd1429096ee8d07793a2fcc,

title = "Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment",

abstract = "Oxidative damage is a feature of many age-related neurodegenerative diseases, including Alzheimer's disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of the free radical-mediated lipid peroxidation of unsaturated lipids, particularly arachidonic acid, in cellular membranes. In the present study we show for the first time in brain obtained at short postmortem intervals that the levels of HNE are elevated in mild cognitive impairment (MCI) hippocampus and inferior parietal lobules compared to those of control brain. Thus, increased levels of HNE in MCI brain implicate lipid peroxidation as an early event in AD pathophysiology and also suggest that the pharmacologic intervention to prevent lipid peroxidation at the MCI stage or earlier may be a promising therapeutic strategy to delay or prevent progression to AD.",

keywords = "4-Hydroxynonenol, Alzheimer's disease, Hippocampus, Inferior parietal lobule, Lipid peroxidation, Mild cognitive impairment, Oxidative stress",

author = "Butterfield, {D. Allan} and Tanea Reed and Marzia Perluigi and {De Marco}, Carlo and Raffaella Coccia and Chiara Cini and Rukhsana Sultana",

note = "Funding Information: The authors would like to thank the University of Kentucky ADRC Clinical Neuropathology Core faculty for providing the brain tissue used for this study. This work was supported in part by NIH grants to D.A.B. [AG-05119; AG-10836].",

year = "2006",

month = apr,

day = "24",

doi = "10.1016/j.neulet.2005.12.017",

language = "English",

volume = "397",

pages = "170--173",

number = "3",

}

TY - JOUR

T1 - Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

AU - Butterfield, D. Allan

AU - Reed, Tanea

AU - Perluigi, Marzia

AU - De Marco, Carlo

AU - Coccia, Raffaella

AU - Cini, Chiara

AU - Sultana, Rukhsana

N1 - Funding Information: The authors would like to thank the University of Kentucky ADRC Clinical Neuropathology Core faculty for providing the brain tissue used for this study. This work was supported in part by NIH grants to D.A.B. [AG-05119; AG-10836].

PY - 2006/4/24

Y1 - 2006/4/24

N2 - Oxidative damage is a feature of many age-related neurodegenerative diseases, including Alzheimer's disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of the free radical-mediated lipid peroxidation of unsaturated lipids, particularly arachidonic acid, in cellular membranes. In the present study we show for the first time in brain obtained at short postmortem intervals that the levels of HNE are elevated in mild cognitive impairment (MCI) hippocampus and inferior parietal lobules compared to those of control brain. Thus, increased levels of HNE in MCI brain implicate lipid peroxidation as an early event in AD pathophysiology and also suggest that the pharmacologic intervention to prevent lipid peroxidation at the MCI stage or earlier may be a promising therapeutic strategy to delay or prevent progression to AD.

AB - Oxidative damage is a feature of many age-related neurodegenerative diseases, including Alzheimer's disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of the free radical-mediated lipid peroxidation of unsaturated lipids, particularly arachidonic acid, in cellular membranes. In the present study we show for the first time in brain obtained at short postmortem intervals that the levels of HNE are elevated in mild cognitive impairment (MCI) hippocampus and inferior parietal lobules compared to those of control brain. Thus, increased levels of HNE in MCI brain implicate lipid peroxidation as an early event in AD pathophysiology and also suggest that the pharmacologic intervention to prevent lipid peroxidation at the MCI stage or earlier may be a promising therapeutic strategy to delay or prevent progression to AD.

KW - 4-Hydroxynonenol

KW - Alzheimer's disease

KW - Hippocampus

KW - Inferior parietal lobule

KW - Lipid peroxidation

KW - Mild cognitive impairment

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=33644987632&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644987632&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2005.12.017

DO - 10.1016/j.neulet.2005.12.017

M3 - Article

C2 - 16413966

AN - SCOPUS:33644987632

SN - 0304-3940

VL - 397

SP - 170

EP - 173

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this