Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

D. Allan Butterfield, Tanea Reed, Marzia Perluigi, Carlo De Marco, Raffaella Coccia, Chiara Cini, Rukhsana Sultana

Research output: Contribution to journalArticlepeer-review

225 Scopus citations

Abstract

Oxidative damage is a feature of many age-related neurodegenerative diseases, including Alzheimer's disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of the free radical-mediated lipid peroxidation of unsaturated lipids, particularly arachidonic acid, in cellular membranes. In the present study we show for the first time in brain obtained at short postmortem intervals that the levels of HNE are elevated in mild cognitive impairment (MCI) hippocampus and inferior parietal lobules compared to those of control brain. Thus, increased levels of HNE in MCI brain implicate lipid peroxidation as an early event in AD pathophysiology and also suggest that the pharmacologic intervention to prevent lipid peroxidation at the MCI stage or earlier may be a promising therapeutic strategy to delay or prevent progression to AD.

Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalNeuroscience Letters
Volume397
Issue number3
DOIs
StatePublished - Apr 24 2006

Bibliographical note

Funding Information:
The authors would like to thank the University of Kentucky ADRC Clinical Neuropathology Core faculty for providing the brain tissue used for this study. This work was supported in part by NIH grants to D.A.B. [AG-05119; AG-10836].

Keywords

  • 4-Hydroxynonenol
  • Alzheimer's disease
  • Hippocampus
  • Inferior parietal lobule
  • Lipid peroxidation
  • Mild cognitive impairment
  • Oxidative stress

ASJC Scopus subject areas

  • General Neuroscience

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