TY - JOUR
T1 - Elevated serum amyloid A levels in cases of aborted equine fetuses due to fetal and placental infections
AU - Erol, Erdal
AU - Jackson, Carney
AU - Horohov, David
AU - Locke, Stephan
AU - Smith, Jacqueline
AU - Carter, Craig
N1 - Publisher Copyright:
© 2016
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Determination of fetal serum amyloid A (SAA) concentrations in aborted fetuses can provide valuable information regarding the infectious and/or inflammatory process of abortion in horses. To investigate the relationship between fetal SAA levels and the infectious/inflammatory disease process in feto-placental tissues, a SAA ELISA was used to test heart serum samples of 89 equine fetuses that were necropsied and diagnosed in the following groups: a multiorgan disease process diagnosed with an identified microorganism (14 cases, group 1); only placentitis diagnosed with an identified microorganism (nine cases, group 2); only placentitis diagnosed with no microorganism identified (six cases, group 3); and no infectious or inflammatory disease process diagnosed (60 cases, group 4). Serum amyloid A concentrations in equine fetuses were elevated from 10.5 to ≥40 mg/L in 10 of 14 cases in group 1; and from less than 2.5 mg/L to greater than 40 mg/L in seven of nine cases in group 2. In group 3, SAA concentrations were found to be less than 2.5 mg/L in five of six cases. In group 4, SAA concentrations were less than 2.5 mg/L in 55 cases, whereas in five cases SAA concentrations were elevated. Statistical significant differences were found between the concentrations of SAA in fetal horse blood and the presence of infectious and/or inflammatory disease process in the feto-placental tissues when a causative microorganism was identified. These results suggest that testing SAA concentrations in fetal heart blood may aid in further understanding the causes of abortions in horses.
AB - Determination of fetal serum amyloid A (SAA) concentrations in aborted fetuses can provide valuable information regarding the infectious and/or inflammatory process of abortion in horses. To investigate the relationship between fetal SAA levels and the infectious/inflammatory disease process in feto-placental tissues, a SAA ELISA was used to test heart serum samples of 89 equine fetuses that were necropsied and diagnosed in the following groups: a multiorgan disease process diagnosed with an identified microorganism (14 cases, group 1); only placentitis diagnosed with an identified microorganism (nine cases, group 2); only placentitis diagnosed with no microorganism identified (six cases, group 3); and no infectious or inflammatory disease process diagnosed (60 cases, group 4). Serum amyloid A concentrations in equine fetuses were elevated from 10.5 to ≥40 mg/L in 10 of 14 cases in group 1; and from less than 2.5 mg/L to greater than 40 mg/L in seven of nine cases in group 2. In group 3, SAA concentrations were found to be less than 2.5 mg/L in five of six cases. In group 4, SAA concentrations were less than 2.5 mg/L in 55 cases, whereas in five cases SAA concentrations were elevated. Statistical significant differences were found between the concentrations of SAA in fetal horse blood and the presence of infectious and/or inflammatory disease process in the feto-placental tissues when a causative microorganism was identified. These results suggest that testing SAA concentrations in fetal heart blood may aid in further understanding the causes of abortions in horses.
KW - Abortion
KW - ELISA
KW - Fetus
KW - Horse
KW - Serum amyloid A
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U2 - 10.1016/j.theriogenology.2016.03.021
DO - 10.1016/j.theriogenology.2016.03.021
M3 - Article
C2 - 27125694
AN - SCOPUS:84964228096
SN - 0093-691X
VL - 86
SP - 971
EP - 975
JO - Theriogenology
JF - Theriogenology
IS - 4
ER -