Elevated serum levels of periostin in patients with allergic bronchopulmonary aspergillosis

Ge Wu, Xun Meng, Peiyan Zheng, Xiaohua Douglas Zhang, Lu Li, Haisheng Hu, Baoqing Sun

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background: Serum periostin levels have been reported to be an indicator of Th2 inflammation in asthmatic patients. Objective: This study aimed to investigate serum levels of periostin in patients with allergic bronchopulmonary aspergillosis (ABPA) and to evaluate its diagnostic and monitoring value in the disease. Methods: Patients with ABPA (n = 19) and asthma (n = 24), including severe asthma with fungal sensitisation (SAFS, n = 11) and severe asthma without fungal sensitization (SAwFS, n = 13), were enrolled. Serum levels of periostin were analysed by enzyme-linked immunosorbent assay. Serum total IgE and Aspergillus fumigatus specific IgE, IgG were measured by ImmunoCAP. Levels of cytokines (IFN-γ, IL-4, IL-5, IL-8, IL-10, IL-13 and IL-17A) were measured by Meso Scale Discovery (MSD). Results: Serum levels of periostin in ABPA patients (85.55 ng/mL, [68.28-166] ng/mL) were higher than those in SAFS (50.99 ng/mL, [32.02-71.80] ng/mL; P < 0.01). Among the analysed cytokines, IL-5 levels in ABPA (1.55 pg/mL, [0.96-3.33] pg/mL) were higher than those in SAFS (0.31 pg/mL, [0.26-0.56] pg/mL; P < 0.05) or SAwFS (0.34 pg/mL, [0.21-0.56] pg/mL; P < 0.01). Serum periostin levels was positively associated with total IgE levels (r = 0.319, P < 0.05), serum IL-5 levels (r = 0.484, P < 0.01) and blood eosinophil counts (r = 0.428, P < 0.05). In ROC analysis, the clinical reference value of periostin was 68.8 ng/mL for differential diagnosis of ABPA and SAFS, with the area under the curve (AUC) of 0.81. Longitudinally, serum periostin levels did not change significantly after treatment in ABPA. Conclusions: These findings suggested that serum levels of periostin were up-regulated in ABPA patients, which may be associated with eosinophilic inflammation.

Original languageEnglish
Pages (from-to)780-789
Number of pages10
JournalMycoses
Volume62
Issue number9
DOIs
StatePublished - 2019

Bibliographical note

Funding Information:
This study was funded by the National Natural Science Foundation of China (Project No.: 81871736, 81802076, 81601394 and 81572063), Bureau of traditional Chinese Medicine Scientific Research Project of Guangdong (Project No.: 20192048), Science and Technology Innovation Committee Project of Guangzhou (Project No.: 201804020043), Open Project of State Key Laboratory of Respiratory Disease (Project No.: SKLRD-OP-201803, SKLRD-OP-201805 and SKLRD-OP-201809) and Guangzhou Education Bureau (201831802).

Funding Information:
This work was supported by the National Natural Science Foundation of China, Scientific research project of Guangdong Provincial Administration of traditional Chinese Medicine and Scientific research projects of Guangzhou Education Bureau. We thank these funders for the support of our study.

Publisher Copyright:
© 2019 Blackwell Verlag GmbH

Keywords

  • allergic bronchopulmonary aspergillosis
  • asthma
  • biomarker
  • periostin

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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