Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory

Yu Zhao; Guigen Zhang

doi:10.1109/ISSPIT.2018.8705145

Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory

Yu Zhao, Guigen Zhang

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

AC electric field at 200 kHz has been used to kill tumor cells, possibly by inducing dielectrophoretic movement of molecules including tubulin and septin, which causes aberrant cell mitosis behavior. Currently no satisfactory models have been developed to elucidate the underlying mechanism. In this paper, we have proposed a modified DEP theory for calculating force in nonhomogeneous particles. By applying the new theory, we find out that the induced interaction between septin filaments is likely to be the main cause of tumor cell death.

Original language	English
Title of host publication	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018
ISBN (Electronic)	9781538675687
DOIs	https://doi.org/10.1109/ISSPIT.2018.8705145
State	Published - Jul 2 2018
Event	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 - Louisville, United States Duration: Dec 6 2018 → Dec 8 2018

Publication series

Name	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018
Volume	2019-January

Conference

Conference	2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018
Country/Territory	United States
City	Louisville
Period	12/6/18 → 12/8/18

Bibliographical note

Publisher Copyright:
© 2018 IEEE.

Keywords

dielectrophoresis (DEP)
microtubule
septin
tubulin
tumor treating fields (TTF)

ASJC Scopus subject areas

Signal Processing
Computer Science Applications
Computer Networks and Communications

Access to Document

10.1109/ISSPIT.2018.8705145

Cite this

Zhao, Y., & Zhang, G. (2018). Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory. In 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 Article 8705145 (2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018; Vol. 2019-January). https://doi.org/10.1109/ISSPIT.2018.8705145

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title = "Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory",

abstract = "AC electric field at 200 kHz has been used to kill tumor cells, possibly by inducing dielectrophoretic movement of molecules including tubulin and septin, which causes aberrant cell mitosis behavior. Currently no satisfactory models have been developed to elucidate the underlying mechanism. In this paper, we have proposed a modified DEP theory for calculating force in nonhomogeneous particles. By applying the new theory, we find out that the induced interaction between septin filaments is likely to be the main cause of tumor cell death.",

keywords = "dielectrophoresis (DEP), microtubule, septin, tubulin, tumor treating fields (TTF)",

author = "Yu Zhao and Guigen Zhang",

note = "Publisher Copyright: {\textcopyright} 2018 IEEE.; 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018 ; Conference date: 06-12-2018 Through 08-12-2018",

year = "2018",

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doi = "10.1109/ISSPIT.2018.8705145",

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Zhao, Y & Zhang, G 2018, Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory. in 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018., 8705145, 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018, vol. 2019-January, 2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018, Louisville, United States, 12/6/18. https://doi.org/10.1109/ISSPIT.2018.8705145

Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory. / Zhao, Yu; Zhang, Guigen.
2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018. 2018. 8705145 (2018 IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2018; Vol. 2019-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

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AU - Zhang, Guigen

PY - 2018/7/2

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N2 - AC electric field at 200 kHz has been used to kill tumor cells, possibly by inducing dielectrophoretic movement of molecules including tubulin and septin, which causes aberrant cell mitosis behavior. Currently no satisfactory models have been developed to elucidate the underlying mechanism. In this paper, we have proposed a modified DEP theory for calculating force in nonhomogeneous particles. By applying the new theory, we find out that the induced interaction between septin filaments is likely to be the main cause of tumor cell death.

AB - AC electric field at 200 kHz has been used to kill tumor cells, possibly by inducing dielectrophoretic movement of molecules including tubulin and septin, which causes aberrant cell mitosis behavior. Currently no satisfactory models have been developed to elucidate the underlying mechanism. In this paper, we have proposed a modified DEP theory for calculating force in nonhomogeneous particles. By applying the new theory, we find out that the induced interaction between septin filaments is likely to be the main cause of tumor cell death.

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Elucidating the mechanism of 200 kHz tumor treating fields with a modified DEP theory

Abstract

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Bibliographical note

Keywords

ASJC Scopus subject areas

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