Emerging roles of xenobiotic detoxification enzymes in metabolic diseases

Michael C. Petriello, Jessie B. Hoffman, Andrew J. Morris, Bernhard Hennig

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Mammalian systems have developed extensive molecular mechanisms to protect against the toxicity of many exogenous xenobiotic compounds. Interestingly, many detoxification enzymes, including cytochrome P450s and flavin-containing monooxygenases, and their associated transcriptional activators [e.g. the aryl hydrocarbon receptor (AhR)], have now been shown to have endogenous roles in normal physiology and the pathology of metabolic diseases. This mini-review will focus on two such instances: the role of flavin-containing monooxygenase 3 (FMO3) in the formation of the cardiometabolic disease biomarker trimethylamine-N-oxide (TMAO) and the role of AhR as a sensor of endogenous ligands such as those generated by the gut microbiota. Understanding the roles of xenobiotic sensing pathways in endogenous metabolism will undoubtedly lead to a better understanding of how exposure to environmental pollutants can perturb these physiological processes.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalReviews on Environmental Health
Issue number1-2
StatePublished - Mar 1 2017

Bibliographical note

Funding Information:
This work was supported in part by the National Institute of Environmental Health Sciences at the National Institutes of Health [P42ES007380].

Publisher Copyright:
© 2017 Walter de Gruyter GmbH, Berlin/Boston.


  • FMO3
  • TMAO
  • cardiovascular disease
  • dioxin
  • metabolic pathologies

ASJC Scopus subject areas

  • Health(social science)
  • Pollution
  • Public Health, Environmental and Occupational Health


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